Targeting KRAS4A splicing through the RBM39/DCAF15 pathway inhibits cancer stem cells

The commonly mutated human KRAS oncogene encodes two distinct KRAS4A and KRAS4B proteins generated by differential splicing. We demonstrate here that coordinated regulation of both isoforms through control of splicing is essential for development of Kras mutant tumors. The minor KRAS4A isoform is en...

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Detalles Bibliográficos
Autores principales: Chen, Wei-Ching, To, Minh D., Westcott, Peter M. K., Delrosario, Reyno, Kim, Il-Jin, Philips, Mark, Tran, Quan, Bollam, Saumya R., Goodarzi, Hani, Bayani, Nora, Mirzoeva, Olga, Balmain, Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277813/
https://www.ncbi.nlm.nih.gov/pubmed/34257283
http://dx.doi.org/10.1038/s41467-021-24498-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277813/
https://www.ncbi.nlm.nih.gov/pubmed/34257283
http://dx.doi.org/10.1038/s41467-021-24498-7

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