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Targeting KRAS4A splicing through the RBM39/DCAF15 pathway inhibits cancer stem cells
The commonly mutated human KRAS oncogene encodes two distinct KRAS4A and KRAS4B proteins generated by differential splicing. We demonstrate here that coordinated regulation of both isoforms through control of splicing is essential for development of Kras mutant tumors. The minor KRAS4A isoform is en...
Autores principales: | Chen, Wei-Ching, To, Minh D., Westcott, Peter M. K., Delrosario, Reyno, Kim, Il-Jin, Philips, Mark, Tran, Quan, Bollam, Saumya R., Goodarzi, Hani, Bayani, Nora, Mirzoeva, Olga, Balmain, Allan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277813/ https://www.ncbi.nlm.nih.gov/pubmed/34257283 http://dx.doi.org/10.1038/s41467-021-24498-7 |
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