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Associations Between Sugars Intakes and Urinary Sugars Excretion and Carbon Stable Isotope Ratios in Red Blood Cells as Biomarkers of Sugars Intake in a Predominantly Māori Population

Determining the extent to which added sugars intake contribute to non-communicable disease in various populations is challenging because it is difficult to accurately measure intakes. Biomarkers may provide a reliable and easily measured method of assessing intakes. In a predominantly Māori populati...

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Autores principales: Te Morenga, Lisa, Kruimer, Devonia, McLean, Rachael, Sabadel, Amandine J. M., van Hale, Robert, Tatin, Xavier, Hindmarsh, Jennié Harre, Mann, Jim, Merriman, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278019/
https://www.ncbi.nlm.nih.gov/pubmed/34277677
http://dx.doi.org/10.3389/fnut.2021.637267
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author Te Morenga, Lisa
Kruimer, Devonia
McLean, Rachael
Sabadel, Amandine J. M.
van Hale, Robert
Tatin, Xavier
Hindmarsh, Jennié Harre
Mann, Jim
Merriman, Tony
author_facet Te Morenga, Lisa
Kruimer, Devonia
McLean, Rachael
Sabadel, Amandine J. M.
van Hale, Robert
Tatin, Xavier
Hindmarsh, Jennié Harre
Mann, Jim
Merriman, Tony
author_sort Te Morenga, Lisa
collection PubMed
description Determining the extent to which added sugars intake contribute to non-communicable disease in various populations is challenging because it is difficult to accurately measure intakes. Biomarkers may provide a reliable and easily measured method of assessing intakes. In a predominantly Māori population we compared various sugars intake estimates derived from a 36 item sugar-specific food frequency questionnaire (FFQ) with biomarkers of sugars intake; urinary sugars excretion in random spot collections (n = 153) and carbon stable isotope ratios (n = 36) in red blood cells (RBCs, δ(13)C(RBC)) and in the alanine fraction of the RBCs (δ(13)C(alanine)). Estimated 24 h urinary sucrose+fructose excretion was statistically significantly correlated with intakes of total sugars (r = 0.23), sucrose (r = 0.26) and added sugars from sugar-sweetened beverages (SSBs; r = 0.26). δ(13)C(alanine) was correlated with added sugars (r = 0.40). In log linear multiple regression models adjusted with HbA1C and eGFR δ(13)C(alanine) predicted added sugars intakes (r(2) = 0.29) and estimated 24 h urinary sucrose+fructose excretion predicted intakes of total sugars (r(2) = 0.14), sucrose (r(2) = 0.17), added sugars (r(2) = 0.17) and sugars from SSBs (r(2) = 0.14). These biomarkers have potential for improving assessment of sugars intake in New Zealand populations enabling monitoring of the effectiveness of sugar reduction strategies designed to reduce risk of NCDs. However, further validation is required to confirm these preliminary findings.
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spelling pubmed-82780192021-07-15 Associations Between Sugars Intakes and Urinary Sugars Excretion and Carbon Stable Isotope Ratios in Red Blood Cells as Biomarkers of Sugars Intake in a Predominantly Māori Population Te Morenga, Lisa Kruimer, Devonia McLean, Rachael Sabadel, Amandine J. M. van Hale, Robert Tatin, Xavier Hindmarsh, Jennié Harre Mann, Jim Merriman, Tony Front Nutr Nutrition Determining the extent to which added sugars intake contribute to non-communicable disease in various populations is challenging because it is difficult to accurately measure intakes. Biomarkers may provide a reliable and easily measured method of assessing intakes. In a predominantly Māori population we compared various sugars intake estimates derived from a 36 item sugar-specific food frequency questionnaire (FFQ) with biomarkers of sugars intake; urinary sugars excretion in random spot collections (n = 153) and carbon stable isotope ratios (n = 36) in red blood cells (RBCs, δ(13)C(RBC)) and in the alanine fraction of the RBCs (δ(13)C(alanine)). Estimated 24 h urinary sucrose+fructose excretion was statistically significantly correlated with intakes of total sugars (r = 0.23), sucrose (r = 0.26) and added sugars from sugar-sweetened beverages (SSBs; r = 0.26). δ(13)C(alanine) was correlated with added sugars (r = 0.40). In log linear multiple regression models adjusted with HbA1C and eGFR δ(13)C(alanine) predicted added sugars intakes (r(2) = 0.29) and estimated 24 h urinary sucrose+fructose excretion predicted intakes of total sugars (r(2) = 0.14), sucrose (r(2) = 0.17), added sugars (r(2) = 0.17) and sugars from SSBs (r(2) = 0.14). These biomarkers have potential for improving assessment of sugars intake in New Zealand populations enabling monitoring of the effectiveness of sugar reduction strategies designed to reduce risk of NCDs. However, further validation is required to confirm these preliminary findings. Frontiers Media S.A. 2021-06-30 /pmc/articles/PMC8278019/ /pubmed/34277677 http://dx.doi.org/10.3389/fnut.2021.637267 Text en Copyright © 2021 Te Morenga, Kruimer, McLean, Sabadel, van Hale, Tatin, Hindmarsh, Mann and Merriman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Te Morenga, Lisa
Kruimer, Devonia
McLean, Rachael
Sabadel, Amandine J. M.
van Hale, Robert
Tatin, Xavier
Hindmarsh, Jennié Harre
Mann, Jim
Merriman, Tony
Associations Between Sugars Intakes and Urinary Sugars Excretion and Carbon Stable Isotope Ratios in Red Blood Cells as Biomarkers of Sugars Intake in a Predominantly Māori Population
title Associations Between Sugars Intakes and Urinary Sugars Excretion and Carbon Stable Isotope Ratios in Red Blood Cells as Biomarkers of Sugars Intake in a Predominantly Māori Population
title_full Associations Between Sugars Intakes and Urinary Sugars Excretion and Carbon Stable Isotope Ratios in Red Blood Cells as Biomarkers of Sugars Intake in a Predominantly Māori Population
title_fullStr Associations Between Sugars Intakes and Urinary Sugars Excretion and Carbon Stable Isotope Ratios in Red Blood Cells as Biomarkers of Sugars Intake in a Predominantly Māori Population
title_full_unstemmed Associations Between Sugars Intakes and Urinary Sugars Excretion and Carbon Stable Isotope Ratios in Red Blood Cells as Biomarkers of Sugars Intake in a Predominantly Māori Population
title_short Associations Between Sugars Intakes and Urinary Sugars Excretion and Carbon Stable Isotope Ratios in Red Blood Cells as Biomarkers of Sugars Intake in a Predominantly Māori Population
title_sort associations between sugars intakes and urinary sugars excretion and carbon stable isotope ratios in red blood cells as biomarkers of sugars intake in a predominantly māori population
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278019/
https://www.ncbi.nlm.nih.gov/pubmed/34277677
http://dx.doi.org/10.3389/fnut.2021.637267
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