Cargando…

Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons

Mutations in the Leucine-rich repeat kinase 2 (LRRK2) gene are the most prevalent cause of familial Parkinson’s disease (PD). The increase in LRRK2 kinase activity observed in the pathogenic G2019S mutation is important for PD development. Several studies have reported that increased LRRK2 kinase ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Hyejung, Sim, Hyuna, Lee, Joo-Eun, Seo, Mi Kyoung, Lim, Juhee, Bang, Yeojin, Nam, Daleum, Lee, Seo-Young, Chung, Sun-Ku, Choi, Hyun Jin, Park, Sung Woo, Son, Ilhong, Kim, Janghwan, Seol, Wongi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society for Brain and Neural Sciences 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278138/ https://www.ncbi.nlm.nih.gov/pubmed/34230223 http://dx.doi.org/10.5607/en21003

Ejemplares similares

Rab GTPases as Physiological Substrates of LRRK2 Kinase
por: Seol, Wongi, et al.
Publicado: (2019)

LRRK2 Kinase Inhibitor Rejuvenates Oxidative Stress-Induced Cellular Senescence in Neuronal Cells
por: Ho, Dong Hwan, et al.
Publicado: (2021)

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression
por: Ho, Dong Hwan, et al.
Publicado: (2015)

Correction to: Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression
por: Ho, Dong Hwan, et al.
Publicado: (2017)

Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity
por: Jang, Jihoon, et al.
Publicado: (2018)

LRRK2 Inhibition Mitigates the Neuroinflammation Caused by TLR2-Specific α-Synuclein and Alleviates Neuroinflammation-Derived Dopaminergic Neuronal Loss
por: Ho, Dong-Hwan, et al.
Publicado: (2022)

Analysis of α-synuclein levels related to LRRK2 kinase activity: from substantia nigra to urine of patients with Parkinson’s disease
por: Nam, Daleum, et al.
Publicado: (2021)

Characterization of Parkinson’s disease-related pathogenic TMEM230 mutants
por: Nam, Daleum, et al.
Publicado: (2018)

Urinary Biomarkers for Neurodegenerative Diseases
por: Seol, Wongi, et al.
Publicado: (2020)

G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses
por: Ho, Dong Hwan, et al.
Publicado: (2019)

G2385R and I2020T Mutations Increase LRRK2 GTPase Activity
por: Ho, Dong Hwan, et al.
Publicado: (2016)

Quantitative Proteomic Analysis of Primitive Neural Stem Cells from LRRK2 G2019S-Associated Parkinson’s Disease Patient-Derived iPSCs
por: Sim, Hyuna, et al.
Publicado: (2020)

LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation
por: Ho, Dong Hwan, et al.
Publicado: (2018)

LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25
por: Yun, Hye Jin, et al.
Publicado: (2013)

Nuclear α-Synuclein-Derived Cytotoxic Effect via Altered Ribosomal RNA Processing in Primary Mouse Embryonic Fibroblasts
por: Ho, Dong Hwan, et al.
Publicado: (2023)

Dexamethasone induces the expression of LRRK2 and α-synuclein, two genes that when mutated cause Parkinson’s disease in an autosomal dominant manner
por: Park, Ji-Min, et al.
Publicado: (2013)

Increased DJ-1 in Urine Exosome of Korean Males with Parkinson's Disease
por: Ho, Dong Hwan, et al.
Publicado: (2014)

Oxidized DJ-1 Levels in Urine Samples as a Putative Biomarker for Parkinson's Disease
por: Jang, Jihoon, et al.
Publicado: (2018)

Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5
por: Heo, Hye Young, et al.
Publicado: (2010)

Neuroprotective Effects of Cryptotanshinone in a Direct Reprogramming Model of Parkinson’s Disease
por: Lee, Joo-Eun, et al.
Publicado: (2020)

Direct Reprogramming to Human Induced Neuronal Progenitors from Fibroblasts of Familial and Sporadic Parkinson’s Disease Patients
por: Lee, Minhyung, et al.
Publicado: (2019)

Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for Parkinson’s Disease
por: Sim, Hyuna, et al.
Publicado: (2020)

Advances in Gene Therapy Techniques to Treat LRRK2 Gene Mutation
por: Chung, Sun-Ku, et al.
Publicado: (2022)

Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia
por: Kim, Beomsue, et al.
Publicado: (2012)

Copine-7 binds to the cell surface receptor, nucleolin, and regulates ciliogenesis and Dspp expression during odontoblast differentiation
por: Seo, You-Mi, et al.
Publicado: (2017)

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
por: Steger, Martin, et al.
Publicado: (2017)

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade
por: Dhekne, Herschel S, et al.
Publicado: (2021)

RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase–mediated centrosomal cohesion and ciliogenesis deficits
por: Lara Ordónez, Antonio Jesús, et al.
Publicado: (2019)

Leucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1
por: Han, Kyung A., et al.
Publicado: (2017)

Localization of PPM1H phosphatase tunes Parkinson’s disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis
por: Yeshaw, Wondwossen M., et al.
Publicado: (2023)

Autophagy and Ciliogenesis
por: Yamamoto, Yasuhiro, et al.
Publicado: (2021)

Differentiated HT22 cells as a novel model for in vitro screening of serotonin reuptake inhibitors
por: Lim, Juhee, et al.
Publicado: (2023)

Rapid Ex-Vivo Ciliogenesis and Dose-Dependent Effect of Notch Inhibition on Ciliogenesis of Respiratory Epithelia
por: Zahid, Maliha, et al.
Publicado: (2020)

Recent advances in the pathology of prodromal non-motor symptoms olfactory deficit and depression in Parkinson’s disease: clues to early diagnosis and effective treatment
por: Bang, Yeojin, et al.
Publicado: (2021)

PS200. Effects of p11 on BDNF-induced changes in dendritic outgrowth and spine formation in primary hippocampal cells
por: Seo, Mi Kyoung, et al.
Publicado: (2016)

LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia
por: Kim, Judong, et al.
Publicado: (2019)

Neuroprotective Effects of Licochalcone D in Oxidative-Stress-Induced Primitive Neural Stem Cells from Parkinson’s Disease Patient-Derived iPSCs
por: Oh, Minyoung, et al.
Publicado: (2023)

Functional genomic screen for modulators of ciliogenesis and cilium length
por: Kim, Joon, et al.
Publicado: (2010)

Inhibition of Autophagy Suppresses Sertraline-Mediated Primary Ciliogenesis in Retinal Pigment Epithelium Cells
por: Kim, Eun Sung, et al.
Publicado: (2015)

Inhibitors of Leucine Rich Repeat Kinase 2 (LRRK2) Protect Against LRRK2-Models of Parkinson’s Disease
por: Lee, Byoung Dae, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_tpeovqlgvecccfp1oc6bihmc52