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Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures
A better understanding of the spatial sensitivity of the human circadian system to photic stimulation can provide practical solutions for optimized circadian light exposures. Two psychophysical experiments, involving 25 adult participants in Experiment 1 (mean age = 34.0 years [SD 15.5]; 13 females)...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278206/ https://www.ncbi.nlm.nih.gov/pubmed/34286162 http://dx.doi.org/10.1016/j.nbscr.2021.100071 |
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author | Nagare, Rohan Rea, Mark S. Figueiro, Mariana G. |
author_facet | Nagare, Rohan Rea, Mark S. Figueiro, Mariana G. |
author_sort | Nagare, Rohan |
collection | PubMed |
description | A better understanding of the spatial sensitivity of the human circadian system to photic stimulation can provide practical solutions for optimized circadian light exposures. Two psychophysical experiments, involving 25 adult participants in Experiment 1 (mean age = 34.0 years [SD 15.5]; 13 females) and 15 adult participants in Experiment 2 (mean age = 43.0 years [SD 12.6]; 12 females), were designed to investigate whether varying only the spatial distribution of luminous stimuli in the environment while maintaining a constant spectrally weighted irradiance at the eye could influence nocturnal melatonin suppression. Two spatial distributions were employed, one where the luminous stimulus was presented On-axis (along the line of sight) and one where two luminous stimuli were both presented Off-axis (laterally displaced at center by 14°). Two narrowband LED light sources, blue (λ(max) = 451 nm) for first experiment and green (λ(max) = 522 nm) for second experiment, were used in both the On-axis and the Off-axis spatial distributions. The blue luminous stimulus targeting the fovea and parafovea (On-axis) was about three times more effective for suppressing melatonin than the photometrically and spectrally matched stimulus targeting the more peripheral retina (Off-axis). The green luminous stimulus targeting the fovea and parafovea (On-axis) was about two times more effective for suppressing melatonin than the photometrically and spectrally matched stimulus targeting the more peripheral retina (Off-axis). |
format | Online Article Text |
id | pubmed-8278206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-82782062021-07-19 Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures Nagare, Rohan Rea, Mark S. Figueiro, Mariana G. Neurobiol Sleep Circadian Rhythms Research Paper A better understanding of the spatial sensitivity of the human circadian system to photic stimulation can provide practical solutions for optimized circadian light exposures. Two psychophysical experiments, involving 25 adult participants in Experiment 1 (mean age = 34.0 years [SD 15.5]; 13 females) and 15 adult participants in Experiment 2 (mean age = 43.0 years [SD 12.6]; 12 females), were designed to investigate whether varying only the spatial distribution of luminous stimuli in the environment while maintaining a constant spectrally weighted irradiance at the eye could influence nocturnal melatonin suppression. Two spatial distributions were employed, one where the luminous stimulus was presented On-axis (along the line of sight) and one where two luminous stimuli were both presented Off-axis (laterally displaced at center by 14°). Two narrowband LED light sources, blue (λ(max) = 451 nm) for first experiment and green (λ(max) = 522 nm) for second experiment, were used in both the On-axis and the Off-axis spatial distributions. The blue luminous stimulus targeting the fovea and parafovea (On-axis) was about three times more effective for suppressing melatonin than the photometrically and spectrally matched stimulus targeting the more peripheral retina (Off-axis). The green luminous stimulus targeting the fovea and parafovea (On-axis) was about two times more effective for suppressing melatonin than the photometrically and spectrally matched stimulus targeting the more peripheral retina (Off-axis). Elsevier 2021-07-03 /pmc/articles/PMC8278206/ /pubmed/34286162 http://dx.doi.org/10.1016/j.nbscr.2021.100071 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Paper Nagare, Rohan Rea, Mark S. Figueiro, Mariana G. Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures |
title | Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures |
title_full | Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures |
title_fullStr | Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures |
title_full_unstemmed | Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures |
title_short | Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures |
title_sort | spatial sensitivity of human circadian response: melatonin suppression from on-axis and off-axis light exposures |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278206/ https://www.ncbi.nlm.nih.gov/pubmed/34286162 http://dx.doi.org/10.1016/j.nbscr.2021.100071 |
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