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Hypothalamus and amygdala functional connectivity at rest in narcolepsy type 1
INTRODUCTION: functional and structural MRI studies suggest that the orexin (hypocretin) deficiency in the dorso-lateral hypothalamus of narcoleptic patients would influence both brain metabolism and perfusion and would cause reduction in cortical grey matter. Previous fMRI studies have mainly focus...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278207/ https://www.ncbi.nlm.nih.gov/pubmed/34252875 http://dx.doi.org/10.1016/j.nicl.2021.102748 |
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author | Ballotta, Daniela Talami, Francesca Pizza, Fabio Vaudano, Anna Elisabetta Benuzzi, Francesca Plazzi, Giuseppe Meletti, Stefano |
author_facet | Ballotta, Daniela Talami, Francesca Pizza, Fabio Vaudano, Anna Elisabetta Benuzzi, Francesca Plazzi, Giuseppe Meletti, Stefano |
author_sort | Ballotta, Daniela |
collection | PubMed |
description | INTRODUCTION: functional and structural MRI studies suggest that the orexin (hypocretin) deficiency in the dorso-lateral hypothalamus of narcoleptic patients would influence both brain metabolism and perfusion and would cause reduction in cortical grey matter. Previous fMRI studies have mainly focused on cerebral functioning during emotional processing. The aim of the present study was to explore the hemodynamic behaviour of spontaneous BOLD fluctuation at rest in patients with Narcolepsy type 1 (NT1) close to disease onset. METHODS: Fifteen drug naïve children/adolescents with NT1 (9 males; mean age 11.7 ± 3 years) and fifteen healthy children/adolescents (9 males; mean age 12.4 ± 2.8 years) participated in an EEG-fMRI study in order to investigate the resting-state functional connectivity of hypothalamus and amygdala. Functional images were acquired on a 3 T system. Seed-based functional connectivity analyses were performed using SPM12. Regions of Interest were the lateral hypothalamus and the amygdala. RESULTS: compared to controls, NT1 patients showed decreased functional connectivity between the lateral hypothalamus and the left superior parietal lobule, the hippocampus and the parahippocampal gyrus. Decreased functional connectivity was detected between the amygdala and the post-central gyrus and several occipital regions, whereas it was increased between the amygdala and the inferior frontal gyrus, claustrum, insula, and putamen. CONCLUSION: in NT1 patients the abnormal connectivity between the hypothalamus and brain regions involved in memory consolidation during sleep, such as the hippocampus, may be linked to the loss of orexin containing neurons in the dorsolateral hypothalamus. Moreover, also functional connectivity of the amygdala seems to be influenced by the loss of orexin-containing neurons. Therefore, we can hypothesize that dysfunctional interactions between regions subserving the maintenance of arousal, memory and emotional processing may contribute to the main symptom of narcolepsy. |
format | Online Article Text |
id | pubmed-8278207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-82782072021-07-19 Hypothalamus and amygdala functional connectivity at rest in narcolepsy type 1 Ballotta, Daniela Talami, Francesca Pizza, Fabio Vaudano, Anna Elisabetta Benuzzi, Francesca Plazzi, Giuseppe Meletti, Stefano Neuroimage Clin Regular Article INTRODUCTION: functional and structural MRI studies suggest that the orexin (hypocretin) deficiency in the dorso-lateral hypothalamus of narcoleptic patients would influence both brain metabolism and perfusion and would cause reduction in cortical grey matter. Previous fMRI studies have mainly focused on cerebral functioning during emotional processing. The aim of the present study was to explore the hemodynamic behaviour of spontaneous BOLD fluctuation at rest in patients with Narcolepsy type 1 (NT1) close to disease onset. METHODS: Fifteen drug naïve children/adolescents with NT1 (9 males; mean age 11.7 ± 3 years) and fifteen healthy children/adolescents (9 males; mean age 12.4 ± 2.8 years) participated in an EEG-fMRI study in order to investigate the resting-state functional connectivity of hypothalamus and amygdala. Functional images were acquired on a 3 T system. Seed-based functional connectivity analyses were performed using SPM12. Regions of Interest were the lateral hypothalamus and the amygdala. RESULTS: compared to controls, NT1 patients showed decreased functional connectivity between the lateral hypothalamus and the left superior parietal lobule, the hippocampus and the parahippocampal gyrus. Decreased functional connectivity was detected between the amygdala and the post-central gyrus and several occipital regions, whereas it was increased between the amygdala and the inferior frontal gyrus, claustrum, insula, and putamen. CONCLUSION: in NT1 patients the abnormal connectivity between the hypothalamus and brain regions involved in memory consolidation during sleep, such as the hippocampus, may be linked to the loss of orexin containing neurons in the dorsolateral hypothalamus. Moreover, also functional connectivity of the amygdala seems to be influenced by the loss of orexin-containing neurons. Therefore, we can hypothesize that dysfunctional interactions between regions subserving the maintenance of arousal, memory and emotional processing may contribute to the main symptom of narcolepsy. Elsevier 2021-07-04 /pmc/articles/PMC8278207/ /pubmed/34252875 http://dx.doi.org/10.1016/j.nicl.2021.102748 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Ballotta, Daniela Talami, Francesca Pizza, Fabio Vaudano, Anna Elisabetta Benuzzi, Francesca Plazzi, Giuseppe Meletti, Stefano Hypothalamus and amygdala functional connectivity at rest in narcolepsy type 1 |
title | Hypothalamus and amygdala functional connectivity at rest in narcolepsy type 1 |
title_full | Hypothalamus and amygdala functional connectivity at rest in narcolepsy type 1 |
title_fullStr | Hypothalamus and amygdala functional connectivity at rest in narcolepsy type 1 |
title_full_unstemmed | Hypothalamus and amygdala functional connectivity at rest in narcolepsy type 1 |
title_short | Hypothalamus and amygdala functional connectivity at rest in narcolepsy type 1 |
title_sort | hypothalamus and amygdala functional connectivity at rest in narcolepsy type 1 |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278207/ https://www.ncbi.nlm.nih.gov/pubmed/34252875 http://dx.doi.org/10.1016/j.nicl.2021.102748 |
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