Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis

Neurodevelopmental disorders are often caused by chromosomal microdeletions comprising numerous contiguous genes. A subset of neurofibromatosis type 1 (NF1) patients with severe developmental delays and intellectual disability harbors such a microdeletion event on chromosome 17q11.2, involving the N...

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Detalles Bibliográficos
Autores principales: Wegscheid, Michelle L., Anastasaki, Corina, Hartigan, Kelly A., Cobb, Olivia M., Papke, Jason B., Traber, Jennifer N., Morris, Stephanie M., Gutmann, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278229/
https://www.ncbi.nlm.nih.gov/pubmed/34233200
http://dx.doi.org/10.1016/j.celrep.2021.109315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278229/
https://www.ncbi.nlm.nih.gov/pubmed/34233200
http://dx.doi.org/10.1016/j.celrep.2021.109315

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