Cargando…
Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine Proteases
Interleukin 7 (IL-7) is a cell growth factor with a central role in normal T cell development, survival and differentiation. The lack of IL-7–IL-7 receptor(R)-mediated signaling compromises lymphoid development, whereas increased signaling activity contributes to the development of chronic inflammat...
Autores principales: | Vandooren, Jennifer, Pereira, Rafaela Vaz Sousa, Ugarte-Berzal, Estefania, Rybakin, Vasily, Noppen, Sam, Stas, Melissa R., Bernaerts, Eline, Ganseman, Eva, Metzemaekers, Mieke, Schols, Dominique, Proost, Paul, Opdenakker, Ghislain |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278288/ https://www.ncbi.nlm.nih.gov/pubmed/34276694 http://dx.doi.org/10.3389/fimmu.2021.701739 |
Ejemplares similares
-
Neutrophils and Activated Macrophages Control Mucosal Immunity by Proteolytic Cleavage of Antileukoproteinase
por: Vandooren, Jennifer, et al.
Publicado: (2018) -
MMP-9/Gelatinase B Degrades Immune Complexes in Systemic Lupus Erythematosus
por: Ugarte-Berzal, Estefania, et al.
Publicado: (2019) -
Propeptide glycosylation and galectin‐3 binding decrease proteolytic activation of human proMMP‐9/progelatinase B
por: Boon, Lise, et al.
Publicado: (2018) -
EDTA/gelatin zymography method to identify C1s versus activated MMP‐9 in plasma and immune complexes of patients with systemic lupus erythematosus
por: Ugarte‐Berzal, Estefania, et al.
Publicado: (2018) -
Glycosylation of matrix metalloproteases and tissue inhibitors: present state, challenges and opportunities
por: Boon, Lise, et al.
Publicado: (2016)