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20S-Hydroxyvitamin D3, a Secosteroid Produced in Humans, Is Anti-Inflammatory and Inhibits Murine Autoimmune Arthritis

The ability to use large doses of vitamin D3 (D3) to chronically treat autoimmune diseases such as rheumatoid arthritis (RA) is prohibitive due to its calcemic effect which can damage vital organs. Cytochrome P450scc (CYP11A1) is able to convert D3 into the noncalcemic analog 20S-hydroxyvitamin D3 [...

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Detalles Bibliográficos
Autores principales:	Postlethwaite, Arnold E., Tuckey, Robert C., Kim, Tae-Kang, Li, Wei, Bhattacharya, Syamal K., Myers, Linda K., Brand, David D., Slominski, Andrzej T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278399/ https://www.ncbi.nlm.nih.gov/pubmed/34276665 http://dx.doi.org/10.3389/fimmu.2021.678487

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