PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant Alzheimer’s disease-causing Presenilin-1 E280A mutation carriers

BACKGROUND: In contrast to sporadic Alzheimer’s disease, autosomal dominant Alzheimer’s disease (ADAD) is associated with greater neuropathological evidence of cerebellar amyloid plaque (Aβ) deposition. In this study, we used positron emission tomography (PET) measurements of fibrillar Aβ burden to...

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Detalles Bibliográficos
Autores principales: Ghisays, Valentina, Lopera, Francisco, Goradia, Dhruman D., Protas, Hillary D., Malek-Ahmadi, Michael H., Chen, Yinghua, Devadas, Vivek, Luo, Ji, Lee, Wendy, Baena, Ana, Bocanegra, Yamile, Guzmán-Vélez, Edmarie, Pardilla-Delgado, Enmanuelle, Vila-Castelar, Clara, Fox-Fuller, Joshua T., Hu, Nan, Clayton, David, Thomas, Ronald G., Alvarez, Sergio, Espinosa, Alejandro, Acosta-Baena, Natalia, Giraldo, Margarita M., Rios-Romenets, Silvia, Langbaum, Jessica B., Chen, Kewei, Su, Yi, Tariot, Pierre N., Quiroz, Yakeel T., Reiman, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278433/
https://www.ncbi.nlm.nih.gov/pubmed/34252876
http://dx.doi.org/10.1016/j.nicl.2021.102749

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