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Comparison of hemoglobin level and neutrophil to lymphocyte ratio as prognostic markers in patients with COVID-19

BACKGROUND: Anemia can negatively affect the outcome of many diseases, including infections and inflammatory conditions. AIM: To compare the prognostic value of hemoglobin level and the neutrophil/lymphocyte ratio (NLR) for prediction of coronavirus disease 2019 (COVID-19) severity. METHODS: In this...

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Autores principales: Fouad, Shaimaa Hani, Allam, Mohamed Farouk, Taha, Sara Ibrahim, Okba, Ahmed Ashraf, Hosny, Amr, Moneer, Mayada, Roman, Sylvia Wefky
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278465/
https://www.ncbi.nlm.nih.gov/pubmed/34250826
http://dx.doi.org/10.1177/03000605211030124
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author Fouad, Shaimaa Hani
Allam, Mohamed Farouk
Taha, Sara Ibrahim
Okba, Ahmed Ashraf
Hosny, Amr
Moneer, Mayada
Roman, Sylvia Wefky
author_facet Fouad, Shaimaa Hani
Allam, Mohamed Farouk
Taha, Sara Ibrahim
Okba, Ahmed Ashraf
Hosny, Amr
Moneer, Mayada
Roman, Sylvia Wefky
author_sort Fouad, Shaimaa Hani
collection PubMed
description BACKGROUND: Anemia can negatively affect the outcome of many diseases, including infections and inflammatory conditions. AIM: To compare the prognostic value of hemoglobin level and the neutrophil/lymphocyte ratio (NLR) for prediction of coronavirus disease 2019 (COVID-19) severity. METHODS: In this retrospective cohort study, clinical data from patients with laboratory-confirmed COVID-19 were collected from hospital records from 10 April 2020 to 30 July 2020. RESULTS: The proportions of patients with mild, moderate, and severe COVID-19 differed significantly in association with hemoglobin levels, neutrophil counts, lymphocyte counts, NLR, and total leukocyte counts. Patients with severe COVID-19 had significantly lower hemoglobin levels than those with moderate or mild COVID-19. There were statistically significant negative associations between hemoglobin and D-dimer, age, and creatinine. The optimal hemoglobin cut-off value for prediction of disease severity was 11.6 g/dL. Using this cut-off value, hemoglobin had higher negative predictive value and sensitivity than NLR (92.4% and 51.3%, respectively). The specificity of hemoglobin as a prognostic marker was 79.3%. CONCLUSION: Both NLR and hemoglobin level are of prognostic value for predicting severity of COVID-19. However, hemoglobin level displayed higher sensitivity than NLR. Hemoglobin level should be assessed upon admission in all patients and closely monitored throughout the disease course.
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spelling pubmed-82784652021-07-20 Comparison of hemoglobin level and neutrophil to lymphocyte ratio as prognostic markers in patients with COVID-19 Fouad, Shaimaa Hani Allam, Mohamed Farouk Taha, Sara Ibrahim Okba, Ahmed Ashraf Hosny, Amr Moneer, Mayada Roman, Sylvia Wefky J Int Med Res Retrospective Clinical Research Report BACKGROUND: Anemia can negatively affect the outcome of many diseases, including infections and inflammatory conditions. AIM: To compare the prognostic value of hemoglobin level and the neutrophil/lymphocyte ratio (NLR) for prediction of coronavirus disease 2019 (COVID-19) severity. METHODS: In this retrospective cohort study, clinical data from patients with laboratory-confirmed COVID-19 were collected from hospital records from 10 April 2020 to 30 July 2020. RESULTS: The proportions of patients with mild, moderate, and severe COVID-19 differed significantly in association with hemoglobin levels, neutrophil counts, lymphocyte counts, NLR, and total leukocyte counts. Patients with severe COVID-19 had significantly lower hemoglobin levels than those with moderate or mild COVID-19. There were statistically significant negative associations between hemoglobin and D-dimer, age, and creatinine. The optimal hemoglobin cut-off value for prediction of disease severity was 11.6 g/dL. Using this cut-off value, hemoglobin had higher negative predictive value and sensitivity than NLR (92.4% and 51.3%, respectively). The specificity of hemoglobin as a prognostic marker was 79.3%. CONCLUSION: Both NLR and hemoglobin level are of prognostic value for predicting severity of COVID-19. However, hemoglobin level displayed higher sensitivity than NLR. Hemoglobin level should be assessed upon admission in all patients and closely monitored throughout the disease course. SAGE Publications 2021-07-11 /pmc/articles/PMC8278465/ /pubmed/34250826 http://dx.doi.org/10.1177/03000605211030124 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Fouad, Shaimaa Hani
Allam, Mohamed Farouk
Taha, Sara Ibrahim
Okba, Ahmed Ashraf
Hosny, Amr
Moneer, Mayada
Roman, Sylvia Wefky
Comparison of hemoglobin level and neutrophil to lymphocyte ratio as prognostic markers in patients with COVID-19
title Comparison of hemoglobin level and neutrophil to lymphocyte ratio as prognostic markers in patients with COVID-19
title_full Comparison of hemoglobin level and neutrophil to lymphocyte ratio as prognostic markers in patients with COVID-19
title_fullStr Comparison of hemoglobin level and neutrophil to lymphocyte ratio as prognostic markers in patients with COVID-19
title_full_unstemmed Comparison of hemoglobin level and neutrophil to lymphocyte ratio as prognostic markers in patients with COVID-19
title_short Comparison of hemoglobin level and neutrophil to lymphocyte ratio as prognostic markers in patients with COVID-19
title_sort comparison of hemoglobin level and neutrophil to lymphocyte ratio as prognostic markers in patients with covid-19
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278465/
https://www.ncbi.nlm.nih.gov/pubmed/34250826
http://dx.doi.org/10.1177/03000605211030124
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