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Mitochondrial dysfunction: A hidden trigger of autism?

Autism is a heterogeneous neurodevelopmental and neuropsychiatric disorder with no precise etiology. Deficits in cognitive functions uncover at early stages and are known to have an environmental and genetic basis. Since autism is multifaceted and also linked with other comorbidities associated with...

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Autores principales: Balachandar, Vellingiri, Rajagopalan, Kamarajan, Jayaramayya, Kaavya, Jeevanandam, Madesh, Iyer, Mahalaxmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278534/
https://www.ncbi.nlm.nih.gov/pubmed/34291134
http://dx.doi.org/10.1016/j.gendis.2020.07.002
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author Balachandar, Vellingiri
Rajagopalan, Kamarajan
Jayaramayya, Kaavya
Jeevanandam, Madesh
Iyer, Mahalaxmi
author_facet Balachandar, Vellingiri
Rajagopalan, Kamarajan
Jayaramayya, Kaavya
Jeevanandam, Madesh
Iyer, Mahalaxmi
author_sort Balachandar, Vellingiri
collection PubMed
description Autism is a heterogeneous neurodevelopmental and neuropsychiatric disorder with no precise etiology. Deficits in cognitive functions uncover at early stages and are known to have an environmental and genetic basis. Since autism is multifaceted and also linked with other comorbidities associated with various organs, there is a possibility that there may be a fundamental cellular process responsible for this. These reasons place mitochondria at the point of interest as it is involved in multiple cellular processes predominantly involving metabolism. Mitochondria encoded genes were taken into consideration lately because it is inherited maternally, has its own genome and also functions the time of embryo development. Various researches have linked mitochondrial mishaps like oxidative stress, ROS production and mt-DNA copy number variations to autism. Despite dramatic advances in autism research worldwide, the studies focusing on mitochondrial dysfunction in autism is rather minimal, especially in India. India, owing to its rich diversity, may be able to contribute significantly to autism research. It is vital to urge more studies in this domain as it may help to completely understand the basics of the condition apart from a genetic standpoint. This review focuses on the worldwide and Indian scenario of autism research; mitochondrial abnormalities in autism and possible therapeutic approaches to combat it.
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spelling pubmed-82785342021-07-20 Mitochondrial dysfunction: A hidden trigger of autism? Balachandar, Vellingiri Rajagopalan, Kamarajan Jayaramayya, Kaavya Jeevanandam, Madesh Iyer, Mahalaxmi Genes Dis Review Article Autism is a heterogeneous neurodevelopmental and neuropsychiatric disorder with no precise etiology. Deficits in cognitive functions uncover at early stages and are known to have an environmental and genetic basis. Since autism is multifaceted and also linked with other comorbidities associated with various organs, there is a possibility that there may be a fundamental cellular process responsible for this. These reasons place mitochondria at the point of interest as it is involved in multiple cellular processes predominantly involving metabolism. Mitochondria encoded genes were taken into consideration lately because it is inherited maternally, has its own genome and also functions the time of embryo development. Various researches have linked mitochondrial mishaps like oxidative stress, ROS production and mt-DNA copy number variations to autism. Despite dramatic advances in autism research worldwide, the studies focusing on mitochondrial dysfunction in autism is rather minimal, especially in India. India, owing to its rich diversity, may be able to contribute significantly to autism research. It is vital to urge more studies in this domain as it may help to completely understand the basics of the condition apart from a genetic standpoint. This review focuses on the worldwide and Indian scenario of autism research; mitochondrial abnormalities in autism and possible therapeutic approaches to combat it. Chongqing Medical University 2020-07-16 /pmc/articles/PMC8278534/ /pubmed/34291134 http://dx.doi.org/10.1016/j.gendis.2020.07.002 Text en © 2020 Chongqing Medical University. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Balachandar, Vellingiri
Rajagopalan, Kamarajan
Jayaramayya, Kaavya
Jeevanandam, Madesh
Iyer, Mahalaxmi
Mitochondrial dysfunction: A hidden trigger of autism?
title Mitochondrial dysfunction: A hidden trigger of autism?
title_full Mitochondrial dysfunction: A hidden trigger of autism?
title_fullStr Mitochondrial dysfunction: A hidden trigger of autism?
title_full_unstemmed Mitochondrial dysfunction: A hidden trigger of autism?
title_short Mitochondrial dysfunction: A hidden trigger of autism?
title_sort mitochondrial dysfunction: a hidden trigger of autism?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278534/
https://www.ncbi.nlm.nih.gov/pubmed/34291134
http://dx.doi.org/10.1016/j.gendis.2020.07.002
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