Myoepithelial Carcinoma of Soft Tissue With an EWSR1-KLF15 Gene Fusion in an Infant

Overall, neonatal cancer is uncommon. Because of its rarity and heterogeneity, diagnosis can be challenging. We report a unique case of a myoepithelial carcinoma in a 7 week old girl. Molecular diagnostic workup revealed a EWSR1-KLF15 gene fusion which was previously described in only six cases of m...

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Autores principales: Bodis, Sandor, Kroiss, Sabine, Tchinda, Joëlle, Fritz, Christine, Wagner, Ulrich, Bode, Peter Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278561/
https://www.ncbi.nlm.nih.gov/pubmed/33734915
http://dx.doi.org/10.1177/1093526621999020
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author Bodis, Sandor
Kroiss, Sabine
Tchinda, Joëlle
Fritz, Christine
Wagner, Ulrich
Bode, Peter Karl
author_facet Bodis, Sandor
Kroiss, Sabine
Tchinda, Joëlle
Fritz, Christine
Wagner, Ulrich
Bode, Peter Karl
author_sort Bodis, Sandor
collection PubMed
description Overall, neonatal cancer is uncommon. Because of its rarity and heterogeneity, diagnosis can be challenging. We report a unique case of a myoepithelial carcinoma in a 7 week old girl. Molecular diagnostic workup revealed a EWSR1-KLF15 gene fusion which was previously described in only six cases of myoepithelial tumors so far. All cases occurred in children and adolescents. To our knowledge, this is the first report of a congenital EWSR1-KLF15 fusion positive myoepithelial tumor in an infant.
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spelling pubmed-82785612021-08-03 Myoepithelial Carcinoma of Soft Tissue With an EWSR1-KLF15 Gene Fusion in an Infant Bodis, Sandor Kroiss, Sabine Tchinda, Joëlle Fritz, Christine Wagner, Ulrich Bode, Peter Karl Pediatr Dev Pathol Case Reports Overall, neonatal cancer is uncommon. Because of its rarity and heterogeneity, diagnosis can be challenging. We report a unique case of a myoepithelial carcinoma in a 7 week old girl. Molecular diagnostic workup revealed a EWSR1-KLF15 gene fusion which was previously described in only six cases of myoepithelial tumors so far. All cases occurred in children and adolescents. To our knowledge, this is the first report of a congenital EWSR1-KLF15 fusion positive myoepithelial tumor in an infant. SAGE Publications 2021-03-18 2021-08 /pmc/articles/PMC8278561/ /pubmed/33734915 http://dx.doi.org/10.1177/1093526621999020 Text en © 2021, Society for Pediatric Pathology All rights reserved https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Bodis, Sandor
Kroiss, Sabine
Tchinda, Joëlle
Fritz, Christine
Wagner, Ulrich
Bode, Peter Karl
Myoepithelial Carcinoma of Soft Tissue With an EWSR1-KLF15 Gene Fusion in an Infant
title Myoepithelial Carcinoma of Soft Tissue With an EWSR1-KLF15 Gene Fusion in an Infant
title_full Myoepithelial Carcinoma of Soft Tissue With an EWSR1-KLF15 Gene Fusion in an Infant
title_fullStr Myoepithelial Carcinoma of Soft Tissue With an EWSR1-KLF15 Gene Fusion in an Infant
title_full_unstemmed Myoepithelial Carcinoma of Soft Tissue With an EWSR1-KLF15 Gene Fusion in an Infant
title_short Myoepithelial Carcinoma of Soft Tissue With an EWSR1-KLF15 Gene Fusion in an Infant
title_sort myoepithelial carcinoma of soft tissue with an ewsr1-klf15 gene fusion in an infant
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278561/
https://www.ncbi.nlm.nih.gov/pubmed/33734915
http://dx.doi.org/10.1177/1093526621999020
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