3D-STED Super-Resolution Microscopy Reveals Distinct Nanoscale Organization of the Hematopoietic Cell-Specific Lyn Substrate-1 (HS1) in Normal and Leukemic B Cells

HS1, the hematopoietic homolog of cortactin, acts as a versatile actin-binding protein in leucocytes. After phosphorylation, it is involved in GTPase and integrin activation, and in BCR, TCR, and CXCR4 downstream signaling. In normal and leukemic B cells, HS1 is a central cytoskeletal interactor and...

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Detalles Bibliográficos
Autores principales: Sampietro, Marta, Zamai, Moreno, Díaz Torres, Alfonsa, Labrador Cantarero, Veronica, Barbaglio, Federica, Scarfò, Lydia, Scielzo, Cristina, Caiolfa, Valeria R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278786/
https://www.ncbi.nlm.nih.gov/pubmed/34277604
http://dx.doi.org/10.3389/fcell.2021.655773

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