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Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes

BACKGROUND: Development of a competent collateral circulation in established coronary artery disease is cardio-protective. The vascular endothelial growth factor (VEGF) system plays a key role in this process. We investigated the prognostic performance of circulating VEGF-A and three genetic variant...

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Autores principales: Palmer, Barry R., Paterson, Melinda A., Frampton, Chris. M., Pilbrow, Anna P., Skelton, Lorraine, Pemberton, Chris J., Doughty, Robert N., Ellis, Chris J., Troughton, Richard W., Richards, A. Mark, Cameron, Vicky A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279389/
https://www.ncbi.nlm.nih.gov/pubmed/34260629
http://dx.doi.org/10.1371/journal.pone.0254206
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author Palmer, Barry R.
Paterson, Melinda A.
Frampton, Chris. M.
Pilbrow, Anna P.
Skelton, Lorraine
Pemberton, Chris J.
Doughty, Robert N.
Ellis, Chris J.
Troughton, Richard W.
Richards, A. Mark
Cameron, Vicky A.
author_facet Palmer, Barry R.
Paterson, Melinda A.
Frampton, Chris. M.
Pilbrow, Anna P.
Skelton, Lorraine
Pemberton, Chris J.
Doughty, Robert N.
Ellis, Chris J.
Troughton, Richard W.
Richards, A. Mark
Cameron, Vicky A.
author_sort Palmer, Barry R.
collection PubMed
description BACKGROUND: Development of a competent collateral circulation in established coronary artery disease is cardio-protective. The vascular endothelial growth factor (VEGF) system plays a key role in this process. We investigated the prognostic performance of circulating VEGF-A and three genetic variants in the VEGFA gene in a clinical coronary cohort. METHODS AND RESULTS: The Coronary Disease Cohort Study (CDCS) recruited 2,140 patients, with a diagnosis of acute coronary syndrome (ACS), after admission to Christchurch or Auckland City Hospitals between July 2002 and January 2009. We present data for 1927 patients from the cohort genotyped for three SNPs in the VEGF-A gene, rs699947 (C-2578A), rs2010963 (C405G) and rs3025039 (C936T). Plasma VEGF-A concentrations were assayed in a subgroup (n = 550) of CDCS patients (geometric mean 36.6 [34.7–38.5] pg/ml). VEGF-A levels correlated with patient heart rate at baseline (p = 0.034). None of rs699947, rs3025039, nor rs2010963 genotypes were significantly associated with VEGF-A levels, but rs3025039 genotype was positively associated with collateral vessels perfusion according to the Rentrop classification (p = 0.01) and baseline natriuretic peptide levels (p<0.05). Survival in the CDCS cohort was independently associated with baseline VEGF-A levels and (in males) with rs699947 genotype. CONCLUSIONS: This study is strongly suggestive that VEGF-A levels have value as a prognostic biomarker in coronary heart disease patients and SNPs in VEGF-A deserve further investigation as prognostic markers and indicators of angiogenic potential influencing the formation of collateral circulation.
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spelling pubmed-82793892021-07-31 Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes Palmer, Barry R. Paterson, Melinda A. Frampton, Chris. M. Pilbrow, Anna P. Skelton, Lorraine Pemberton, Chris J. Doughty, Robert N. Ellis, Chris J. Troughton, Richard W. Richards, A. Mark Cameron, Vicky A. PLoS One Research Article BACKGROUND: Development of a competent collateral circulation in established coronary artery disease is cardio-protective. The vascular endothelial growth factor (VEGF) system plays a key role in this process. We investigated the prognostic performance of circulating VEGF-A and three genetic variants in the VEGFA gene in a clinical coronary cohort. METHODS AND RESULTS: The Coronary Disease Cohort Study (CDCS) recruited 2,140 patients, with a diagnosis of acute coronary syndrome (ACS), after admission to Christchurch or Auckland City Hospitals between July 2002 and January 2009. We present data for 1927 patients from the cohort genotyped for three SNPs in the VEGF-A gene, rs699947 (C-2578A), rs2010963 (C405G) and rs3025039 (C936T). Plasma VEGF-A concentrations were assayed in a subgroup (n = 550) of CDCS patients (geometric mean 36.6 [34.7–38.5] pg/ml). VEGF-A levels correlated with patient heart rate at baseline (p = 0.034). None of rs699947, rs3025039, nor rs2010963 genotypes were significantly associated with VEGF-A levels, but rs3025039 genotype was positively associated with collateral vessels perfusion according to the Rentrop classification (p = 0.01) and baseline natriuretic peptide levels (p<0.05). Survival in the CDCS cohort was independently associated with baseline VEGF-A levels and (in males) with rs699947 genotype. CONCLUSIONS: This study is strongly suggestive that VEGF-A levels have value as a prognostic biomarker in coronary heart disease patients and SNPs in VEGF-A deserve further investigation as prognostic markers and indicators of angiogenic potential influencing the formation of collateral circulation. Public Library of Science 2021-07-14 /pmc/articles/PMC8279389/ /pubmed/34260629 http://dx.doi.org/10.1371/journal.pone.0254206 Text en © 2021 Palmer et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Palmer, Barry R.
Paterson, Melinda A.
Frampton, Chris. M.
Pilbrow, Anna P.
Skelton, Lorraine
Pemberton, Chris J.
Doughty, Robert N.
Ellis, Chris J.
Troughton, Richard W.
Richards, A. Mark
Cameron, Vicky A.
Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes
title Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes
title_full Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes
title_fullStr Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes
title_full_unstemmed Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes
title_short Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes
title_sort vascular endothelial growth factor-a promoter polymorphisms, circulating vegf-a and survival in acute coronary syndromes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279389/
https://www.ncbi.nlm.nih.gov/pubmed/34260629
http://dx.doi.org/10.1371/journal.pone.0254206
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