Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their In Vivo Adjuvant Activity

[Image: see text] We report on the design, synthesis, and biological evaluation of a series of nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) desmuramylpeptide agonists with improved in vitro and in vivo adjuvant properties. We identified two promising compounds: 68, a potent...

Descripción completa

Detalles Bibliográficos
Autores principales: Guzelj, Samo, Nabergoj, Sanja, Gobec, Martina, Pajk, Stane, Klančič, Veronika, Slütter, Bram, Frkanec, Ruža, Štimac, Adela, Šket, Primož, Plavec, Janez, Mlinarič-Raščan, Irena, Jakopin, Žiga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279416/
https://www.ncbi.nlm.nih.gov/pubmed/34043358
http://dx.doi.org/10.1021/acs.jmedchem.1c00644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279416/
https://www.ncbi.nlm.nih.gov/pubmed/34043358
http://dx.doi.org/10.1021/acs.jmedchem.1c00644

Ejemplares similares