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Structural Fine-Tuning of Desmuramylpeptide NOD2 Agonists Defines Their In Vivo Adjuvant Activity

[Image: see text] We report on the design, synthesis, and biological evaluation of a series of nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) desmuramylpeptide agonists with improved in vitro and in vivo adjuvant properties. We identified two promising compounds: 68, a potent...

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Detalles Bibliográficos
Autores principales:	Guzelj, Samo, Nabergoj, Sanja, Gobec, Martina, Pajk, Stane, Klančič, Veronika, Slütter, Bram, Frkanec, Ruža, Štimac, Adela, Šket, Primož, Plavec, Janez, Mlinarič-Raščan, Irena, Jakopin, Žiga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279416/ https://www.ncbi.nlm.nih.gov/pubmed/34043358 http://dx.doi.org/10.1021/acs.jmedchem.1c00644

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