Solid-Phase Synthesis of Gly-Ψ[CH(CF(3))NH]-Peptides

[Image: see text] The solid-phase synthesis of Gly-Ψ[CH(CF(3))NH]-peptides is presented. In order to achieve this goal, the synthesis of Gly-Ψ[CH(CF(3))NH]-dipeptides having the C-terminus unprotected, the N-terminus protected as Fmoc- or Teoc-, and possibly side chain functionalities protected with...

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Detalles Bibliográficos
Autores principales: Sgorbati, Clara, Lo Presti, Eliana, Bergamaschi, Greta, Sani, Monica, Volonterio, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279481/
https://www.ncbi.nlm.nih.gov/pubmed/34081467
http://dx.doi.org/10.1021/acs.joc.1c00853
Descripción
Sumario:[Image: see text] The solid-phase synthesis of Gly-Ψ[CH(CF(3))NH]-peptides is presented. In order to achieve this goal, the synthesis of Gly-Ψ[CH(CF(3))NH]-dipeptides having the C-terminus unprotected, the N-terminus protected as Fmoc- or Teoc-, and possibly side chain functionalities protected with acid-labile protecting groups has been developed. A selected small library of six peptidomimetics, encompassing analogues of biological relevant peptides, have been obtained in high purity.

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