Solid-Phase Synthesis of Gly-Ψ[CH(CF(3))NH]-Peptides

[Image: see text] The solid-phase synthesis of Gly-Ψ[CH(CF(3))NH]-peptides is presented. In order to achieve this goal, the synthesis of Gly-Ψ[CH(CF(3))NH]-dipeptides having the C-terminus unprotected, the N-terminus protected as Fmoc- or Teoc-, and possibly side chain functionalities protected with...

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Autores principales: Sgorbati, Clara, Lo Presti, Eliana, Bergamaschi, Greta, Sani, Monica, Volonterio, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279481/
https://www.ncbi.nlm.nih.gov/pubmed/34081467
http://dx.doi.org/10.1021/acs.joc.1c00853
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author Sgorbati, Clara
Lo Presti, Eliana
Bergamaschi, Greta
Sani, Monica
Volonterio, Alessandro
author_facet Sgorbati, Clara
Lo Presti, Eliana
Bergamaschi, Greta
Sani, Monica
Volonterio, Alessandro
author_sort Sgorbati, Clara
collection PubMed
description [Image: see text] The solid-phase synthesis of Gly-Ψ[CH(CF(3))NH]-peptides is presented. In order to achieve this goal, the synthesis of Gly-Ψ[CH(CF(3))NH]-dipeptides having the C-terminus unprotected, the N-terminus protected as Fmoc- or Teoc-, and possibly side chain functionalities protected with acid-labile protecting groups has been developed. A selected small library of six peptidomimetics, encompassing analogues of biological relevant peptides, have been obtained in high purity.
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spelling pubmed-82794812021-07-15 Solid-Phase Synthesis of Gly-Ψ[CH(CF(3))NH]-Peptides Sgorbati, Clara Lo Presti, Eliana Bergamaschi, Greta Sani, Monica Volonterio, Alessandro J Org Chem [Image: see text] The solid-phase synthesis of Gly-Ψ[CH(CF(3))NH]-peptides is presented. In order to achieve this goal, the synthesis of Gly-Ψ[CH(CF(3))NH]-dipeptides having the C-terminus unprotected, the N-terminus protected as Fmoc- or Teoc-, and possibly side chain functionalities protected with acid-labile protecting groups has been developed. A selected small library of six peptidomimetics, encompassing analogues of biological relevant peptides, have been obtained in high purity. American Chemical Society 2021-06-03 2021-07-02 /pmc/articles/PMC8279481/ /pubmed/34081467 http://dx.doi.org/10.1021/acs.joc.1c00853 Text en © 2021 The Authors. Published by American Chemical Society Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Sgorbati, Clara
Lo Presti, Eliana
Bergamaschi, Greta
Sani, Monica
Volonterio, Alessandro
Solid-Phase Synthesis of Gly-Ψ[CH(CF(3))NH]-Peptides
title Solid-Phase Synthesis of Gly-Ψ[CH(CF(3))NH]-Peptides
title_full Solid-Phase Synthesis of Gly-Ψ[CH(CF(3))NH]-Peptides
title_fullStr Solid-Phase Synthesis of Gly-Ψ[CH(CF(3))NH]-Peptides
title_full_unstemmed Solid-Phase Synthesis of Gly-Ψ[CH(CF(3))NH]-Peptides
title_short Solid-Phase Synthesis of Gly-Ψ[CH(CF(3))NH]-Peptides
title_sort solid-phase synthesis of gly-ψ[ch(cf(3))nh]-peptides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279481/
https://www.ncbi.nlm.nih.gov/pubmed/34081467
http://dx.doi.org/10.1021/acs.joc.1c00853
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