The mechanism of gap creation by a multifunctional nuclease during base excision repair

During base excision repair, a transient single-stranded DNA (ssDNA) gap is produced at the apurinic/apyrimidinic (AP) site. Exonuclease III, capable of performing both AP endonuclease and exonuclease activity, are responsible for gap creation in bacteria. We used single-molecule fluorescence resona...

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Detalles Bibliográficos
Autores principales: Yoo, Jungmin, Lee, Donghun, Im, Hyeryeon, Ji, Sangmi, Oh, Sanghoon, Shin, Minsang, Park, Daeho, Lee, Gwangrog
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279506/
https://www.ncbi.nlm.nih.gov/pubmed/34261654
http://dx.doi.org/10.1126/sciadv.abg0076

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