Cargando…

MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease

Parkinson’s disease (PD) is the second most widespread neurodegenerative disorder in the world. It has been reported that exosomes derived from mesenchymal stem cells (MSCs) can contribute to the recovery of PD. However, the underlying mechanism remains poorly defined. In this study, proteomics and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xue, Chunling, Li, Xuechun, Ba, Li, Zhang, Mingjia, Yang, Ying, Gao, Yang, Sun, Zhao, Han, Qin, Zhao, Robert Chunhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	JKL International LLC 2021
Materias:	Orginal Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279521/ https://www.ncbi.nlm.nih.gov/pubmed/34341703 http://dx.doi.org/10.14336/AD.2020.1221

Ejemplares similares

Human Adipose Mesenchymal Stem Cell-derived Exosomes Protect Mice from DSS-Induced Inflammatory Bowel Disease by Promoting Intestinal-stem-cell and Epithelial Regeneration
por: Yu, Hongliang, et al.
Publicado: (2021)

HIF-1α promotes the migration and invasion of cancer-associated fibroblasts by miR-210
por: Yang, Ying, et al.
Publicado: (2021)

Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a
por: Xu, Meiqian, et al.
Publicado: (2021)

The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson’s Disease
por: Zhao, Yong-Fei, et al.
Publicado: (2018)

Disease Progression-Dependent Expression of CD200R1 and CX3CR1 in Mouse Models of Parkinson’s Disease
por: Wang, Le, et al.
Publicado: (2020)

Entorhinal Cortex Atrophy in Early, Drug-naive Parkinson’s Disease with Mild Cognitive Impairment
por: Jia, Xiuqin, et al.
Publicado: (2019)

MiR-1292 Targets FZD4 to Regulate Senescence and Osteogenic Differentiation of Stem Cells in TE/SJ/Mesenchymal Tissue System via the Wnt/β-catenin Pathway
por: Fan, Junfen, et al.
Publicado: (2018)

MiRNA-10b Reciprocally Stimulates Osteogenesis and Inhibits Adipogenesis Partly through the TGF-β/SMAD2 Signaling Pathway
por: Li, Hongling, et al.
Publicado: (2018)

Trefoil Factor 3, Cholinesterase and Homocysteine: Potential Predictors for Parkinson’s Disease Dementia and Vascular Parkinsonism Dementia in Advanced Stage
por: Zou, Jing, et al.
Publicado: (2018)

Limb Ischemic Conditioning Improved Cognitive Deficits via eNOS-Dependent Augmentation of Angiogenesis after Chronic Cerebral Hypoperfusion in Rats
por: Ren, Changhong, et al.
Publicado: (2018)

Six Visual Rating Scales as A Biomarker for Monitoring Atrophied Brain Volume in Parkinson’s Disease
por: Lin, Yu, et al.
Publicado: (2020)

Gait Characteristics and Brain Activity in Parkinson’s Disease with Concomitant Postural Abnormalities
por: Yao, Meng-sha, et al.
Publicado: (2020)

Mitochondrial Creatine Kinase is Decreased in the Serum of Idiopathic Parkinson’s Disease Patients
por: Xu, Jinghui, et al.
Publicado: (2019)

Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson’s Disease
por: Zhang, Li, et al.
Publicado: (2018)

Chondroprotective Effects of Combination Therapy of Acupotomy and Human Adipose Mesenchymal Stem Cells in Knee Osteoarthritis Rabbits via the GSK3β-Cyclin D1-CDK4/CDK6 Signaling Pathway
por: An, Xingyan, et al.
Publicado: (2020)

CLARITY for High-resolution Imaging and Quantification of Vasculature in the Whole Mouse Brain
por: Zhang, Lin-Yuan, et al.
Publicado: (2018)

The Metabolic Activity of Caudate and Prefrontal Cortex Negatively Correlates with the Severity of Idiopathic Parkinson’s Disease
por: Chu, Jun-Sheng, et al.
Publicado: (2019)

T1-weighted MRI-driven Brain Age Estimation in Alzheimer’s Disease and Parkinson’s Disease
por: Beheshti, Iman, et al.
Publicado: (2019)

Muscle Fatigue Does Not Change the Effects on Lower Limbs Strength Caused by Aging and Parkinson’s Disease
por: Alota Ignacio Pereira, Vinicius, et al.
Publicado: (2018)

Verapamil Ameliorates Motor Neuron Degeneration and Improves Lifespan in the SOD1(G93A) Mouse Model of ALS by Enhancing Autophagic Flux
por: Zhang, Xiaojie, et al.
Publicado: (2019)

Clinical Profile of Chinese Long-Term Parkinson’s Disease Survivors With 10 Years of Disease Duration and Beyond
por: Sun, Qian, et al.
Publicado: (2018)

Systematic Study of Immune Cell Diversity in ischemic postconditioning Using High-Dimensional Single-Cell Analysis with Mass Cytometry
por: Yao, Yang, et al.
Publicado: (2021)

MSC-derived exosomes promote recovery from traumatic brain injury via microglia/macrophages in rat
por: Chen, Yunfei, et al.
Publicado: (2020)

Utilizing Electronic Medical Records to Discover Changing Trends of Medical Behaviors Over Time(*)
por: Yin, Liangying, et al.
Publicado: (2017)

Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering
por: Zhang, Shuyuan, et al.
Publicado: (2019)

Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice
por: Li, Danyang, et al.
Publicado: (2021)

Hydroxyurea Facilitates Manifestation of Disease Relevant Phenotypes in Patients-Derived IPSCs-Based Modeling of Late-Onset Parkinson’s Disease
por: Tan, Yuan, et al.
Publicado: (2019)

Transplantation of ACE2(-) Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia
por: Leng, Zikuan, et al.
Publicado: (2020)

Deficiency of Endothelial Nitric Oxide Synthase (eNOS) Exacerbates Brain Damage and Cognitive Deficit in A Mouse Model of Vascular Dementia
por: An, Lulu, et al.
Publicado: (2021)

Involvement of Kif4a in Spindle Formation and Chromosome Segregation in Mouse Oocytes
por: Tang, Feng, et al.
Publicado: (2018)

Olfactory Dysfunction and Its Relationship with Clinical Symptoms of Alzheimer Disease
por: Yu, Qiujin, et al.
Publicado: (2018)

The Mechanism of Downregulated Interstitial Fluid Drainage Following Neuronal Excitation
por: Li, Yuanyuan, et al.
Publicado: (2020)

Artemisinin Improved Neuronal Functions in Alzheimer's Disease Animal Model 3xtg Mice and Neuronal Cells via Stimulating the ERK/CREB Signaling Pathway
por: Zhao, Xia, et al.
Publicado: (2020)

Neuropsychological Deficits Chronically Developed after Focal Ischemic Stroke and Beneficial Effects of Pharmacological Hypothermia in the Mouse
por: Zhong, Weiwei, et al.
Publicado: (2020)

Nilotinib Improves Bioenergetic Profiling in Brain Astroglia in the 3xTg Mouse Model of Alzheimer’s Disease
por: Adlimoghaddam, Aida, et al.
Publicado: (2021)

Brain-derived CCR5 Contributes to Neuroprotection and Brain Repair after Experimental Stroke
por: Ping, Suning, et al.
Publicado: (2021)

Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice
por: Guo, Xingzhi, et al.
Publicado: (2020)

Prior Antithrombotic Therapy is Associated with Increased Risk of Death in Patients with Intracerebral Hemorrhage: Findings from the Chinese Stroke Center Alliance (CSCA) Study
por: Liu, Dacheng, et al.
Publicado: (2021)

Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension
por: Li, Tangzhiming, et al.
Publicado: (2019)

NLRC3: A Novel Noninvasive Biomarker for Pulmonary Hypertension Diagnosis
por: Zha, Li-huang, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_m0lmv811bfsaefebo78g53ktjc