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tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases

tRNA-derived fragments (tRFs), which are non-coding RNAs produced via tRNA cleavage with lengths of 14 to 50 nucleotides, originate from precursor tRNAs or mature tRNAs and exist in a wide range of organisms. tRFs are produced not by random fracture of tRNAs but by specific mechanisms. Considerable...

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Autores principales: Yuan, Ya, Li, Jiamei, He, Zhi, Fan, Xiaolan, Mao, Xueping, Yang, Mingyao, Yang, Deying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279533/
https://www.ncbi.nlm.nih.gov/pubmed/34341710
http://dx.doi.org/10.14336/AD.2021.0115
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author Yuan, Ya
Li, Jiamei
He, Zhi
Fan, Xiaolan
Mao, Xueping
Yang, Mingyao
Yang, Deying
author_facet Yuan, Ya
Li, Jiamei
He, Zhi
Fan, Xiaolan
Mao, Xueping
Yang, Mingyao
Yang, Deying
author_sort Yuan, Ya
collection PubMed
description tRNA-derived fragments (tRFs), which are non-coding RNAs produced via tRNA cleavage with lengths of 14 to 50 nucleotides, originate from precursor tRNAs or mature tRNAs and exist in a wide range of organisms. tRFs are produced not by random fracture of tRNAs but by specific mechanisms. Considerable evidence shows that tRFs are detectable in model organisms of different ages and are associated with age-related diseases in humans, such as cancer and neurodegenerative diseases. In this literature review, the origin and classification of tRFs and the regulatory mechanisms of tRFs in aging and age-related diseases are summarized. We also describe the available tRF databases and research techniques and lay a foundation for the exploration of tRFs as biomarkers for the diagnosis and treatment of aging and age-related diseases.
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spelling pubmed-82795332021-08-01 tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases Yuan, Ya Li, Jiamei He, Zhi Fan, Xiaolan Mao, Xueping Yang, Mingyao Yang, Deying Aging Dis Review Article tRNA-derived fragments (tRFs), which are non-coding RNAs produced via tRNA cleavage with lengths of 14 to 50 nucleotides, originate from precursor tRNAs or mature tRNAs and exist in a wide range of organisms. tRFs are produced not by random fracture of tRNAs but by specific mechanisms. Considerable evidence shows that tRFs are detectable in model organisms of different ages and are associated with age-related diseases in humans, such as cancer and neurodegenerative diseases. In this literature review, the origin and classification of tRFs and the regulatory mechanisms of tRFs in aging and age-related diseases are summarized. We also describe the available tRF databases and research techniques and lay a foundation for the exploration of tRFs as biomarkers for the diagnosis and treatment of aging and age-related diseases. JKL International LLC 2021-08-01 /pmc/articles/PMC8279533/ /pubmed/34341710 http://dx.doi.org/10.14336/AD.2021.0115 Text en copyright: © 2021 Yuan et al. https://creativecommons.org/licenses/by/2.0/this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review Article
Yuan, Ya
Li, Jiamei
He, Zhi
Fan, Xiaolan
Mao, Xueping
Yang, Mingyao
Yang, Deying
tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases
title tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases
title_full tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases
title_fullStr tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases
title_full_unstemmed tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases
title_short tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases
title_sort trna-derived fragments as new hallmarks of aging and age-related diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279533/
https://www.ncbi.nlm.nih.gov/pubmed/34341710
http://dx.doi.org/10.14336/AD.2021.0115
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