An aberrant inflammatory response in severe COVID-19

Severe COVID-19 arises from the convergence of inadequate pre-existing immunity and a host response that damages, rather than repairs, tissues. We outline clinical presentations of COVID-19 that are likely driven by dysregulated host immunity, discuss potential mechanisms underlying pathological res...

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Detalles Bibliográficos
Autores principales: Merad, Miriam, Subramanian, Aruna, Wang, Taia T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279571/
https://www.ncbi.nlm.nih.gov/pubmed/34265243
http://dx.doi.org/10.1016/j.chom.2021.06.018
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author Merad, Miriam
Subramanian, Aruna
Wang, Taia T.
author_facet Merad, Miriam
Subramanian, Aruna
Wang, Taia T.
author_sort Merad, Miriam
collection PubMed
description Severe COVID-19 arises from the convergence of inadequate pre-existing immunity and a host response that damages, rather than repairs, tissues. We outline clinical presentations of COVID-19 that are likely driven by dysregulated host immunity, discuss potential mechanisms underlying pathological responses, and highlight important areas for basic research on this topic.
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spelling pubmed-82795712021-07-20 An aberrant inflammatory response in severe COVID-19 Merad, Miriam Subramanian, Aruna Wang, Taia T. Cell Host Microbe Forum Severe COVID-19 arises from the convergence of inadequate pre-existing immunity and a host response that damages, rather than repairs, tissues. We outline clinical presentations of COVID-19 that are likely driven by dysregulated host immunity, discuss potential mechanisms underlying pathological responses, and highlight important areas for basic research on this topic. Elsevier Inc. 2021-07-14 2021-07-14 /pmc/articles/PMC8279571/ /pubmed/34265243 http://dx.doi.org/10.1016/j.chom.2021.06.018 Text en © 2021 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Forum
Merad, Miriam
Subramanian, Aruna
Wang, Taia T.
An aberrant inflammatory response in severe COVID-19
title An aberrant inflammatory response in severe COVID-19
title_full An aberrant inflammatory response in severe COVID-19
title_fullStr An aberrant inflammatory response in severe COVID-19
title_full_unstemmed An aberrant inflammatory response in severe COVID-19
title_short An aberrant inflammatory response in severe COVID-19
title_sort aberrant inflammatory response in severe covid-19
topic Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279571/
https://www.ncbi.nlm.nih.gov/pubmed/34265243
http://dx.doi.org/10.1016/j.chom.2021.06.018
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