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Outcomes for continuous subcutaneous insulin infusion users in young adults from lower socioeconomic backgrounds

OBJECTIVE: Diabetes technology is available and its efficacy and safety have been demonstrated; however, there is little evidence as to how this technology is being utilized and its effectiveness in vulnerable populations. This study evaluated differences in outcomes for young adults in the United S...

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Autores principales: McKee, Alexis M., Albert, Stewart G., Al‐Hammadi, Noor, Hinyard, Leslie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279595/
https://www.ncbi.nlm.nih.gov/pubmed/34277976
http://dx.doi.org/10.1002/edm2.252
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author McKee, Alexis M.
Albert, Stewart G.
Al‐Hammadi, Noor
Hinyard, Leslie J.
author_facet McKee, Alexis M.
Albert, Stewart G.
Al‐Hammadi, Noor
Hinyard, Leslie J.
author_sort McKee, Alexis M.
collection PubMed
description OBJECTIVE: Diabetes technology is available and its efficacy and safety have been demonstrated; however, there is little evidence as to how this technology is being utilized and its effectiveness in vulnerable populations. This study evaluated differences in outcomes for young adults in the United States (U.S.) from lower socioeconomic (SES) backgrounds with type 1 diabetes (T1D) managed on continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDI) or fixed‐dose insulin (FDI). RESEARCH DESIGN, METHODS AND PARTICIPANTS: Utilizing the Optum® de‐identified Electronic Health Record data set between 2008 and 2018 to perform a retrospective, cohort study, we identified 805 subjects with T1D aged 18–30 years with Medicaid. We evaluated median difference in HbA1c between CSII and MDI/FDI users for 24 months. Predictors of diabetic ketoacidosis (DKA)‐associated hospitalizations by CSII use were evaluated using logistic regression. RESULTS: CSII users showed statistically significant lower median HbA1c values at 24 months of follow‐up compared to individuals on MDI/FDI. Non‐white individuals were at lower odds of receiving treatment with CSII. Subjects on CSII were not more likely to be hospitalized for DKA compared to subjects treated with MDI/FDI. Older subjects were at lower odds of being hospitalized for DKA. Males and subjects followed by Endocrinologists were at higher odds of being hospitalized for DKA. CONCLUSIONS: Young adults with T1D from lower SES backgrounds show improved glycaemic control when in CSII compared to MDI/FDI without increases in hospitalizations for DKA.
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spelling pubmed-82795952021-07-15 Outcomes for continuous subcutaneous insulin infusion users in young adults from lower socioeconomic backgrounds McKee, Alexis M. Albert, Stewart G. Al‐Hammadi, Noor Hinyard, Leslie J. Endocrinol Diabetes Metab Original Research Articles OBJECTIVE: Diabetes technology is available and its efficacy and safety have been demonstrated; however, there is little evidence as to how this technology is being utilized and its effectiveness in vulnerable populations. This study evaluated differences in outcomes for young adults in the United States (U.S.) from lower socioeconomic (SES) backgrounds with type 1 diabetes (T1D) managed on continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDI) or fixed‐dose insulin (FDI). RESEARCH DESIGN, METHODS AND PARTICIPANTS: Utilizing the Optum® de‐identified Electronic Health Record data set between 2008 and 2018 to perform a retrospective, cohort study, we identified 805 subjects with T1D aged 18–30 years with Medicaid. We evaluated median difference in HbA1c between CSII and MDI/FDI users for 24 months. Predictors of diabetic ketoacidosis (DKA)‐associated hospitalizations by CSII use were evaluated using logistic regression. RESULTS: CSII users showed statistically significant lower median HbA1c values at 24 months of follow‐up compared to individuals on MDI/FDI. Non‐white individuals were at lower odds of receiving treatment with CSII. Subjects on CSII were not more likely to be hospitalized for DKA compared to subjects treated with MDI/FDI. Older subjects were at lower odds of being hospitalized for DKA. Males and subjects followed by Endocrinologists were at higher odds of being hospitalized for DKA. CONCLUSIONS: Young adults with T1D from lower SES backgrounds show improved glycaemic control when in CSII compared to MDI/FDI without increases in hospitalizations for DKA. John Wiley and Sons Inc. 2021-05-14 /pmc/articles/PMC8279595/ /pubmed/34277976 http://dx.doi.org/10.1002/edm2.252 Text en © 2021 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Articles
McKee, Alexis M.
Albert, Stewart G.
Al‐Hammadi, Noor
Hinyard, Leslie J.
Outcomes for continuous subcutaneous insulin infusion users in young adults from lower socioeconomic backgrounds
title Outcomes for continuous subcutaneous insulin infusion users in young adults from lower socioeconomic backgrounds
title_full Outcomes for continuous subcutaneous insulin infusion users in young adults from lower socioeconomic backgrounds
title_fullStr Outcomes for continuous subcutaneous insulin infusion users in young adults from lower socioeconomic backgrounds
title_full_unstemmed Outcomes for continuous subcutaneous insulin infusion users in young adults from lower socioeconomic backgrounds
title_short Outcomes for continuous subcutaneous insulin infusion users in young adults from lower socioeconomic backgrounds
title_sort outcomes for continuous subcutaneous insulin infusion users in young adults from lower socioeconomic backgrounds
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279595/
https://www.ncbi.nlm.nih.gov/pubmed/34277976
http://dx.doi.org/10.1002/edm2.252
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