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COVID‐19 in a country with a very high prevalence of diabetes: The impact of admission hyperglycaemia on mortality

AIMS: To evaluate the frequency of diabetes and admission hyperglycaemia in Mexican COVID‐19 patients, to describe the clinical and biochemical characteristics of patients with admission hyperglycaemia and to determinate the impact of diabetes and admission hyperglycaemia on COVID‐19 severity and mo...

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Autores principales: Martínez‐Murillo, Carlos, Ramos Peñafiel, Christian, Basurto, Lourdes, Balcázar‐Hernández, Lourdes, Pellón, Karen, Flores López, Eder, Li Gómez, Beatriz, Ledesma, Mercedes Estefania, Rivera Tapia, Rodrigo, Madera Maldonado, Elizabeth, Bejarano Rosales, Monica, Barranco Lampon, Gilberto, Zazueta, Juan Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279620/
https://www.ncbi.nlm.nih.gov/pubmed/34277995
http://dx.doi.org/10.1002/edm2.279
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author Martínez‐Murillo, Carlos
Ramos Peñafiel, Christian
Basurto, Lourdes
Balcázar‐Hernández, Lourdes
Pellón, Karen
Flores López, Eder
Li Gómez, Beatriz
Ledesma, Mercedes Estefania
Rivera Tapia, Rodrigo
Madera Maldonado, Elizabeth
Bejarano Rosales, Monica
Barranco Lampon, Gilberto
Zazueta, Juan Francisco
author_facet Martínez‐Murillo, Carlos
Ramos Peñafiel, Christian
Basurto, Lourdes
Balcázar‐Hernández, Lourdes
Pellón, Karen
Flores López, Eder
Li Gómez, Beatriz
Ledesma, Mercedes Estefania
Rivera Tapia, Rodrigo
Madera Maldonado, Elizabeth
Bejarano Rosales, Monica
Barranco Lampon, Gilberto
Zazueta, Juan Francisco
author_sort Martínez‐Murillo, Carlos
collection PubMed
description AIMS: To evaluate the frequency of diabetes and admission hyperglycaemia in Mexican COVID‐19 patients, to describe the clinical and biochemical characteristics of patients with admission hyperglycaemia and to determinate the impact of diabetes and admission hyperglycaemia on COVID‐19 severity and mortality. METHODS: A multicentric study was performed in 480 hospitalized patients with COVID‐19. Clinical and biochemical characteristics were evaluated in patients with admission hyperglycaemia and compared with non‐hyperglycaemic patients. The effect of diabetes and admission hyperglycaemia on severity and risk of death were evaluated. RESULTS: Age was 50.7 ± 13.6 years; 68.3% were male. Some 48.5% (n = 233) had admission hyperglycaemia; 29% (n = 139) of these patients had pre‐existing diabetes. Patients with admission hyperglycaemia had more requirement of invasive mechanical ventilation (IMV), higher levels of urea, D‐dimer and neutrophil‐lymphocyte ratio (NLR), as well as lower lymphocyte count. An association between admission hyperglycaemia with IMV and D‐dimer with glucose was found. Age ≥50 years (OR 2.09; 95%CI 1.37–3.17), pre‐existing diabetes (OR 2.38; 95%CI 1.59–5.04) and admission hyperglycaemia (OR 8.24; 95%CI 4.74–14.32) were risk factors for mortality. CONCLUSIONS: Admission hyperglycaemia is presented in 48.5% of COVID‐19 patients. Diabetes and admission hyperglycaemia are associated with the severity of disease and mortality. This study shows the devastating conjunction of hyperglycaemia and COVID‐19. Clinical trial registration: Clinical characteristics of patients with COVID‐19, DI/20/204/04/41 (Hospital General de Mexico) and NR‐13‐2020 (Hospital Regional de Alta Especialidad Ixtapaluca).
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spelling pubmed-82796202021-07-15 COVID‐19 in a country with a very high prevalence of diabetes: The impact of admission hyperglycaemia on mortality Martínez‐Murillo, Carlos Ramos Peñafiel, Christian Basurto, Lourdes Balcázar‐Hernández, Lourdes Pellón, Karen Flores López, Eder Li Gómez, Beatriz Ledesma, Mercedes Estefania Rivera Tapia, Rodrigo Madera Maldonado, Elizabeth Bejarano Rosales, Monica Barranco Lampon, Gilberto Zazueta, Juan Francisco Endocrinol Diabetes Metab Original Research Articles AIMS: To evaluate the frequency of diabetes and admission hyperglycaemia in Mexican COVID‐19 patients, to describe the clinical and biochemical characteristics of patients with admission hyperglycaemia and to determinate the impact of diabetes and admission hyperglycaemia on COVID‐19 severity and mortality. METHODS: A multicentric study was performed in 480 hospitalized patients with COVID‐19. Clinical and biochemical characteristics were evaluated in patients with admission hyperglycaemia and compared with non‐hyperglycaemic patients. The effect of diabetes and admission hyperglycaemia on severity and risk of death were evaluated. RESULTS: Age was 50.7 ± 13.6 years; 68.3% were male. Some 48.5% (n = 233) had admission hyperglycaemia; 29% (n = 139) of these patients had pre‐existing diabetes. Patients with admission hyperglycaemia had more requirement of invasive mechanical ventilation (IMV), higher levels of urea, D‐dimer and neutrophil‐lymphocyte ratio (NLR), as well as lower lymphocyte count. An association between admission hyperglycaemia with IMV and D‐dimer with glucose was found. Age ≥50 years (OR 2.09; 95%CI 1.37–3.17), pre‐existing diabetes (OR 2.38; 95%CI 1.59–5.04) and admission hyperglycaemia (OR 8.24; 95%CI 4.74–14.32) were risk factors for mortality. CONCLUSIONS: Admission hyperglycaemia is presented in 48.5% of COVID‐19 patients. Diabetes and admission hyperglycaemia are associated with the severity of disease and mortality. This study shows the devastating conjunction of hyperglycaemia and COVID‐19. Clinical trial registration: Clinical characteristics of patients with COVID‐19, DI/20/204/04/41 (Hospital General de Mexico) and NR‐13‐2020 (Hospital Regional de Alta Especialidad Ixtapaluca). John Wiley and Sons Inc. 2021-06-14 /pmc/articles/PMC8279620/ /pubmed/34277995 http://dx.doi.org/10.1002/edm2.279 Text en © 2021 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Articles
Martínez‐Murillo, Carlos
Ramos Peñafiel, Christian
Basurto, Lourdes
Balcázar‐Hernández, Lourdes
Pellón, Karen
Flores López, Eder
Li Gómez, Beatriz
Ledesma, Mercedes Estefania
Rivera Tapia, Rodrigo
Madera Maldonado, Elizabeth
Bejarano Rosales, Monica
Barranco Lampon, Gilberto
Zazueta, Juan Francisco
COVID‐19 in a country with a very high prevalence of diabetes: The impact of admission hyperglycaemia on mortality
title COVID‐19 in a country with a very high prevalence of diabetes: The impact of admission hyperglycaemia on mortality
title_full COVID‐19 in a country with a very high prevalence of diabetes: The impact of admission hyperglycaemia on mortality
title_fullStr COVID‐19 in a country with a very high prevalence of diabetes: The impact of admission hyperglycaemia on mortality
title_full_unstemmed COVID‐19 in a country with a very high prevalence of diabetes: The impact of admission hyperglycaemia on mortality
title_short COVID‐19 in a country with a very high prevalence of diabetes: The impact of admission hyperglycaemia on mortality
title_sort covid‐19 in a country with a very high prevalence of diabetes: the impact of admission hyperglycaemia on mortality
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279620/
https://www.ncbi.nlm.nih.gov/pubmed/34277995
http://dx.doi.org/10.1002/edm2.279
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