Atypical Thyroid Function Tests and Thyroid Hormone Resistance

Clinical interpretation of thyroid labs is usually straightforward. However, there are rare instances when the atypical profile of thyroid labs warrants systematic investigation to determine the underlying cause. We report the case of a 90-year-old Caucasian male with a chronic history of atrial fib...

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Detalles Bibliográficos
Autores principales: Pattan, Vishwanath, Mehra, Ishita, Khan, Syed Anjum, Kashyap, Rahul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279904/
https://www.ncbi.nlm.nih.gov/pubmed/34306893
http://dx.doi.org/10.7759/cureus.16328
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author Pattan, Vishwanath
Mehra, Ishita
Khan, Syed Anjum
Kashyap, Rahul
author_facet Pattan, Vishwanath
Mehra, Ishita
Khan, Syed Anjum
Kashyap, Rahul
author_sort Pattan, Vishwanath
collection PubMed
description Clinical interpretation of thyroid labs is usually straightforward. However, there are rare instances when the atypical profile of thyroid labs warrants systematic investigation to determine the underlying cause. We report the case of a 90-year-old Caucasian male with a chronic history of atrial fibrillation with chronic pacemaker dependence who presented with significantly elevated free thyroxine level (>7.77 ng/dL) but normal thyroid-stimulating hormone level (2.15 µIU/mL). After ruling out pituitary tumors and artifactual errors due to lab interference, the diagnosis of thyroid hormone resistance was made.
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spelling pubmed-82799042021-07-22 Atypical Thyroid Function Tests and Thyroid Hormone Resistance Pattan, Vishwanath Mehra, Ishita Khan, Syed Anjum Kashyap, Rahul Cureus Endocrinology/Diabetes/Metabolism Clinical interpretation of thyroid labs is usually straightforward. However, there are rare instances when the atypical profile of thyroid labs warrants systematic investigation to determine the underlying cause. We report the case of a 90-year-old Caucasian male with a chronic history of atrial fibrillation with chronic pacemaker dependence who presented with significantly elevated free thyroxine level (>7.77 ng/dL) but normal thyroid-stimulating hormone level (2.15 µIU/mL). After ruling out pituitary tumors and artifactual errors due to lab interference, the diagnosis of thyroid hormone resistance was made. Cureus 2021-07-12 /pmc/articles/PMC8279904/ /pubmed/34306893 http://dx.doi.org/10.7759/cureus.16328 Text en Copyright © 2021, Pattan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Pattan, Vishwanath
Mehra, Ishita
Khan, Syed Anjum
Kashyap, Rahul
Atypical Thyroid Function Tests and Thyroid Hormone Resistance
title Atypical Thyroid Function Tests and Thyroid Hormone Resistance
title_full Atypical Thyroid Function Tests and Thyroid Hormone Resistance
title_fullStr Atypical Thyroid Function Tests and Thyroid Hormone Resistance
title_full_unstemmed Atypical Thyroid Function Tests and Thyroid Hormone Resistance
title_short Atypical Thyroid Function Tests and Thyroid Hormone Resistance
title_sort atypical thyroid function tests and thyroid hormone resistance
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279904/
https://www.ncbi.nlm.nih.gov/pubmed/34306893
http://dx.doi.org/10.7759/cureus.16328
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