N-Methyl-D-Aspartate Receptor-Negative Autoimmune Encephalitis in a Patient With an Ovarian Teratoma and an Associated Novel Cerebrospinal Fluid Autoantibody

Autoimmune encephalitis is most commonly caused by autoantibodies against N-methyl-D-aspartate (NMDA) receptors, and the malignancy most often associated with anti-NMDA receptor autoimmune encephalitis is an ovarian teratoma. Here, we describe a case of autoimmune encephalitis caused by a newly disc...

Descripción completa

Detalles Bibliográficos
Autores principales: Chaudhuri, Munir A, Lucas, Jason M, Chandra, Mona, Silver, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279908/
https://www.ncbi.nlm.nih.gov/pubmed/34306894
http://dx.doi.org/10.7759/cureus.16334
_version_ 1783722540850479104
author Chaudhuri, Munir A
Lucas, Jason M
Chandra, Mona
Silver, Michael
author_facet Chaudhuri, Munir A
Lucas, Jason M
Chandra, Mona
Silver, Michael
author_sort Chaudhuri, Munir A
collection PubMed
description Autoimmune encephalitis is most commonly caused by autoantibodies against N-methyl-D-aspartate (NMDA) receptors, and the malignancy most often associated with anti-NMDA receptor autoimmune encephalitis is an ovarian teratoma. Here, we describe a case of autoimmune encephalitis caused by a newly discovered cerebrospinal fluid autoantibody that has not been previously described and is not anti-NMDA receptor-mediated, which has been associated with an ovarian teratoma. It was successfully treated with high-dose corticosteroids and plasmapheresis followed by rituximab and chemotherapy (paclitaxel, ifosfamide, and cisplatin) for her teratoma.
format Online
Article
Text
id pubmed-8279908
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-82799082021-07-22 N-Methyl-D-Aspartate Receptor-Negative Autoimmune Encephalitis in a Patient With an Ovarian Teratoma and an Associated Novel Cerebrospinal Fluid Autoantibody Chaudhuri, Munir A Lucas, Jason M Chandra, Mona Silver, Michael Cureus Internal Medicine Autoimmune encephalitis is most commonly caused by autoantibodies against N-methyl-D-aspartate (NMDA) receptors, and the malignancy most often associated with anti-NMDA receptor autoimmune encephalitis is an ovarian teratoma. Here, we describe a case of autoimmune encephalitis caused by a newly discovered cerebrospinal fluid autoantibody that has not been previously described and is not anti-NMDA receptor-mediated, which has been associated with an ovarian teratoma. It was successfully treated with high-dose corticosteroids and plasmapheresis followed by rituximab and chemotherapy (paclitaxel, ifosfamide, and cisplatin) for her teratoma. Cureus 2021-07-12 /pmc/articles/PMC8279908/ /pubmed/34306894 http://dx.doi.org/10.7759/cureus.16334 Text en Copyright © 2021, Chaudhuri et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Chaudhuri, Munir A
Lucas, Jason M
Chandra, Mona
Silver, Michael
N-Methyl-D-Aspartate Receptor-Negative Autoimmune Encephalitis in a Patient With an Ovarian Teratoma and an Associated Novel Cerebrospinal Fluid Autoantibody
title N-Methyl-D-Aspartate Receptor-Negative Autoimmune Encephalitis in a Patient With an Ovarian Teratoma and an Associated Novel Cerebrospinal Fluid Autoantibody
title_full N-Methyl-D-Aspartate Receptor-Negative Autoimmune Encephalitis in a Patient With an Ovarian Teratoma and an Associated Novel Cerebrospinal Fluid Autoantibody
title_fullStr N-Methyl-D-Aspartate Receptor-Negative Autoimmune Encephalitis in a Patient With an Ovarian Teratoma and an Associated Novel Cerebrospinal Fluid Autoantibody
title_full_unstemmed N-Methyl-D-Aspartate Receptor-Negative Autoimmune Encephalitis in a Patient With an Ovarian Teratoma and an Associated Novel Cerebrospinal Fluid Autoantibody
title_short N-Methyl-D-Aspartate Receptor-Negative Autoimmune Encephalitis in a Patient With an Ovarian Teratoma and an Associated Novel Cerebrospinal Fluid Autoantibody
title_sort n-methyl-d-aspartate receptor-negative autoimmune encephalitis in a patient with an ovarian teratoma and an associated novel cerebrospinal fluid autoantibody
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279908/
https://www.ncbi.nlm.nih.gov/pubmed/34306894
http://dx.doi.org/10.7759/cureus.16334
work_keys_str_mv AT chaudhurimunira nmethyldaspartatereceptornegativeautoimmuneencephalitisinapatientwithanovarianteratomaandanassociatednovelcerebrospinalfluidautoantibody
AT lucasjasonm nmethyldaspartatereceptornegativeautoimmuneencephalitisinapatientwithanovarianteratomaandanassociatednovelcerebrospinalfluidautoantibody
AT chandramona nmethyldaspartatereceptornegativeautoimmuneencephalitisinapatientwithanovarianteratomaandanassociatednovelcerebrospinalfluidautoantibody
AT silvermichael nmethyldaspartatereceptornegativeautoimmuneencephalitisinapatientwithanovarianteratomaandanassociatednovelcerebrospinalfluidautoantibody

Ejemplares similares