From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio

Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-...

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Detalles Bibliográficos
Autores principales: Arkin, Lisa M., Moon, John J., Tran, Jennifer M., Asgari, Samira, O’Farrelly, Cliona, Casanova, Jean-Laurent, Cowen, Edward W., Mays, Jacqueline W., Singh, Anne Marie, Drolet, Beth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: . Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279931/
https://www.ncbi.nlm.nih.gov/pubmed/34561087
http://dx.doi.org/10.1016/j.jid.2021.05.024
Descripción
Sumario:Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.

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