The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex

Chronic pain is associated with persistent but reversible structural and functional changes in the prefrontal cortex (PFC). This stable yet malleable plasticity implicates epigenetic mechanisms, including DNA methylation, as a potential mediator of chronic pain–induced cortical pathology. We previou...

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Detalles Bibliográficos
Autores principales: Topham, Lucas, Gregoire, Stephanie, Kang, HyungMo, Salmon-Divon, Mali, Lax, Elad, Millecamps, Magali, Szyf, Moshe, Stone, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280078/
https://www.ncbi.nlm.nih.gov/pubmed/34278163
http://dx.doi.org/10.1097/PR9.0000000000000944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280078/
https://www.ncbi.nlm.nih.gov/pubmed/34278163
http://dx.doi.org/10.1097/PR9.0000000000000944

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