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Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study

Periodontal disease is a chronic inflammatory condition that affects various peripheral organs. The periodontal inflamed surface area (PISA) quantifies periodontitis severity and the spread of inflammatory wounds. This study aimed to investigate the association between PISA and high-sensitivity C-re...

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Autores principales: Miki, Koji, Kitamura, Masahiro, Hatta, Kodai, Kamide, Kei, Gondo, Yasuyuki, Yamashita, Motozo, Takedachi, Masahide, Nozaki, Takenori, Fujihara, Chiharu, Kashiwagi, Yoichiro, Iwayama, Tomoaki, Takahashi, Toshihito, Sato, Hitomi, Murotani, Yuki, Kabayama, Mai, Takeya, Yasushi, Takami, Yoichi, Akasaka, Hiroshi, Yamamoto, Koichi, Sugimoto, Ken, Ishizaki, Tatsuro, Masui, Yukie, Rakugi, Hiromi, Ikebe, Kazunori, Murakami, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280099/
https://www.ncbi.nlm.nih.gov/pubmed/34262126
http://dx.doi.org/10.1038/s41598-021-93872-8
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author Miki, Koji
Kitamura, Masahiro
Hatta, Kodai
Kamide, Kei
Gondo, Yasuyuki
Yamashita, Motozo
Takedachi, Masahide
Nozaki, Takenori
Fujihara, Chiharu
Kashiwagi, Yoichiro
Iwayama, Tomoaki
Takahashi, Toshihito
Sato, Hitomi
Murotani, Yuki
Kabayama, Mai
Takeya, Yasushi
Takami, Yoichi
Akasaka, Hiroshi
Yamamoto, Koichi
Sugimoto, Ken
Ishizaki, Tatsuro
Masui, Yukie
Rakugi, Hiromi
Ikebe, Kazunori
Murakami, Shinya
author_facet Miki, Koji
Kitamura, Masahiro
Hatta, Kodai
Kamide, Kei
Gondo, Yasuyuki
Yamashita, Motozo
Takedachi, Masahide
Nozaki, Takenori
Fujihara, Chiharu
Kashiwagi, Yoichiro
Iwayama, Tomoaki
Takahashi, Toshihito
Sato, Hitomi
Murotani, Yuki
Kabayama, Mai
Takeya, Yasushi
Takami, Yoichi
Akasaka, Hiroshi
Yamamoto, Koichi
Sugimoto, Ken
Ishizaki, Tatsuro
Masui, Yukie
Rakugi, Hiromi
Ikebe, Kazunori
Murakami, Shinya
author_sort Miki, Koji
collection PubMed
description Periodontal disease is a chronic inflammatory condition that affects various peripheral organs. The periodontal inflamed surface area (PISA) quantifies periodontitis severity and the spread of inflammatory wounds. This study aimed to investigate the association between PISA and high-sensitivity C-reactive protein (hs-CRP), a systemic inflammation marker. This study included 250 community-dwelling septuagenarians (69–71 years). We collected information on their medical (e.g., diabetes and dyslipidemia) and dental examinations (e.g., measurement of the probing pocket depth). Generalized linear model analysis was used to explore the association between PISA and hs-CRP levels. There was a significant difference in hs-CRP levels between groups with PISA ≥ 500 and < 500 (p = 0.017). Moreover, the generalized linear model analysis revealed a significant association between PISA and hs-CRP levels (risk ratio = 1.77; p = 0.033) even after adjusting other factors. Further, we found a correlation between PISA and hs-CRP (Spearman’s rank correlation coefficient, rs = 0.181; p = 0.023). Our findings suggest that PISA is an effective index for estimating the effect of periodontitis on the whole body, enabling medical-dental cooperation.
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spelling pubmed-82800992021-07-15 Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study Miki, Koji Kitamura, Masahiro Hatta, Kodai Kamide, Kei Gondo, Yasuyuki Yamashita, Motozo Takedachi, Masahide Nozaki, Takenori Fujihara, Chiharu Kashiwagi, Yoichiro Iwayama, Tomoaki Takahashi, Toshihito Sato, Hitomi Murotani, Yuki Kabayama, Mai Takeya, Yasushi Takami, Yoichi Akasaka, Hiroshi Yamamoto, Koichi Sugimoto, Ken Ishizaki, Tatsuro Masui, Yukie Rakugi, Hiromi Ikebe, Kazunori Murakami, Shinya Sci Rep Article Periodontal disease is a chronic inflammatory condition that affects various peripheral organs. The periodontal inflamed surface area (PISA) quantifies periodontitis severity and the spread of inflammatory wounds. This study aimed to investigate the association between PISA and high-sensitivity C-reactive protein (hs-CRP), a systemic inflammation marker. This study included 250 community-dwelling septuagenarians (69–71 years). We collected information on their medical (e.g., diabetes and dyslipidemia) and dental examinations (e.g., measurement of the probing pocket depth). Generalized linear model analysis was used to explore the association between PISA and hs-CRP levels. There was a significant difference in hs-CRP levels between groups with PISA ≥ 500 and < 500 (p = 0.017). Moreover, the generalized linear model analysis revealed a significant association between PISA and hs-CRP levels (risk ratio = 1.77; p = 0.033) even after adjusting other factors. Further, we found a correlation between PISA and hs-CRP (Spearman’s rank correlation coefficient, rs = 0.181; p = 0.023). Our findings suggest that PISA is an effective index for estimating the effect of periodontitis on the whole body, enabling medical-dental cooperation. Nature Publishing Group UK 2021-07-14 /pmc/articles/PMC8280099/ /pubmed/34262126 http://dx.doi.org/10.1038/s41598-021-93872-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Miki, Koji
Kitamura, Masahiro
Hatta, Kodai
Kamide, Kei
Gondo, Yasuyuki
Yamashita, Motozo
Takedachi, Masahide
Nozaki, Takenori
Fujihara, Chiharu
Kashiwagi, Yoichiro
Iwayama, Tomoaki
Takahashi, Toshihito
Sato, Hitomi
Murotani, Yuki
Kabayama, Mai
Takeya, Yasushi
Takami, Yoichi
Akasaka, Hiroshi
Yamamoto, Koichi
Sugimoto, Ken
Ishizaki, Tatsuro
Masui, Yukie
Rakugi, Hiromi
Ikebe, Kazunori
Murakami, Shinya
Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study
title Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study
title_full Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study
title_fullStr Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study
title_full_unstemmed Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study
title_short Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study
title_sort periodontal inflamed surface area is associated with hs-crp in septuagenarian japanese adults in cross-sectional findings from the sonic study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280099/
https://www.ncbi.nlm.nih.gov/pubmed/34262126
http://dx.doi.org/10.1038/s41598-021-93872-8
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