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Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study
Periodontal disease is a chronic inflammatory condition that affects various peripheral organs. The periodontal inflamed surface area (PISA) quantifies periodontitis severity and the spread of inflammatory wounds. This study aimed to investigate the association between PISA and high-sensitivity C-re...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280099/ https://www.ncbi.nlm.nih.gov/pubmed/34262126 http://dx.doi.org/10.1038/s41598-021-93872-8 |
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author | Miki, Koji Kitamura, Masahiro Hatta, Kodai Kamide, Kei Gondo, Yasuyuki Yamashita, Motozo Takedachi, Masahide Nozaki, Takenori Fujihara, Chiharu Kashiwagi, Yoichiro Iwayama, Tomoaki Takahashi, Toshihito Sato, Hitomi Murotani, Yuki Kabayama, Mai Takeya, Yasushi Takami, Yoichi Akasaka, Hiroshi Yamamoto, Koichi Sugimoto, Ken Ishizaki, Tatsuro Masui, Yukie Rakugi, Hiromi Ikebe, Kazunori Murakami, Shinya |
author_facet | Miki, Koji Kitamura, Masahiro Hatta, Kodai Kamide, Kei Gondo, Yasuyuki Yamashita, Motozo Takedachi, Masahide Nozaki, Takenori Fujihara, Chiharu Kashiwagi, Yoichiro Iwayama, Tomoaki Takahashi, Toshihito Sato, Hitomi Murotani, Yuki Kabayama, Mai Takeya, Yasushi Takami, Yoichi Akasaka, Hiroshi Yamamoto, Koichi Sugimoto, Ken Ishizaki, Tatsuro Masui, Yukie Rakugi, Hiromi Ikebe, Kazunori Murakami, Shinya |
author_sort | Miki, Koji |
collection | PubMed |
description | Periodontal disease is a chronic inflammatory condition that affects various peripheral organs. The periodontal inflamed surface area (PISA) quantifies periodontitis severity and the spread of inflammatory wounds. This study aimed to investigate the association between PISA and high-sensitivity C-reactive protein (hs-CRP), a systemic inflammation marker. This study included 250 community-dwelling septuagenarians (69–71 years). We collected information on their medical (e.g., diabetes and dyslipidemia) and dental examinations (e.g., measurement of the probing pocket depth). Generalized linear model analysis was used to explore the association between PISA and hs-CRP levels. There was a significant difference in hs-CRP levels between groups with PISA ≥ 500 and < 500 (p = 0.017). Moreover, the generalized linear model analysis revealed a significant association between PISA and hs-CRP levels (risk ratio = 1.77; p = 0.033) even after adjusting other factors. Further, we found a correlation between PISA and hs-CRP (Spearman’s rank correlation coefficient, rs = 0.181; p = 0.023). Our findings suggest that PISA is an effective index for estimating the effect of periodontitis on the whole body, enabling medical-dental cooperation. |
format | Online Article Text |
id | pubmed-8280099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82800992021-07-15 Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study Miki, Koji Kitamura, Masahiro Hatta, Kodai Kamide, Kei Gondo, Yasuyuki Yamashita, Motozo Takedachi, Masahide Nozaki, Takenori Fujihara, Chiharu Kashiwagi, Yoichiro Iwayama, Tomoaki Takahashi, Toshihito Sato, Hitomi Murotani, Yuki Kabayama, Mai Takeya, Yasushi Takami, Yoichi Akasaka, Hiroshi Yamamoto, Koichi Sugimoto, Ken Ishizaki, Tatsuro Masui, Yukie Rakugi, Hiromi Ikebe, Kazunori Murakami, Shinya Sci Rep Article Periodontal disease is a chronic inflammatory condition that affects various peripheral organs. The periodontal inflamed surface area (PISA) quantifies periodontitis severity and the spread of inflammatory wounds. This study aimed to investigate the association between PISA and high-sensitivity C-reactive protein (hs-CRP), a systemic inflammation marker. This study included 250 community-dwelling septuagenarians (69–71 years). We collected information on their medical (e.g., diabetes and dyslipidemia) and dental examinations (e.g., measurement of the probing pocket depth). Generalized linear model analysis was used to explore the association between PISA and hs-CRP levels. There was a significant difference in hs-CRP levels between groups with PISA ≥ 500 and < 500 (p = 0.017). Moreover, the generalized linear model analysis revealed a significant association between PISA and hs-CRP levels (risk ratio = 1.77; p = 0.033) even after adjusting other factors. Further, we found a correlation between PISA and hs-CRP (Spearman’s rank correlation coefficient, rs = 0.181; p = 0.023). Our findings suggest that PISA is an effective index for estimating the effect of periodontitis on the whole body, enabling medical-dental cooperation. Nature Publishing Group UK 2021-07-14 /pmc/articles/PMC8280099/ /pubmed/34262126 http://dx.doi.org/10.1038/s41598-021-93872-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Miki, Koji Kitamura, Masahiro Hatta, Kodai Kamide, Kei Gondo, Yasuyuki Yamashita, Motozo Takedachi, Masahide Nozaki, Takenori Fujihara, Chiharu Kashiwagi, Yoichiro Iwayama, Tomoaki Takahashi, Toshihito Sato, Hitomi Murotani, Yuki Kabayama, Mai Takeya, Yasushi Takami, Yoichi Akasaka, Hiroshi Yamamoto, Koichi Sugimoto, Ken Ishizaki, Tatsuro Masui, Yukie Rakugi, Hiromi Ikebe, Kazunori Murakami, Shinya Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study |
title | Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study |
title_full | Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study |
title_fullStr | Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study |
title_full_unstemmed | Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study |
title_short | Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study |
title_sort | periodontal inflamed surface area is associated with hs-crp in septuagenarian japanese adults in cross-sectional findings from the sonic study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280099/ https://www.ncbi.nlm.nih.gov/pubmed/34262126 http://dx.doi.org/10.1038/s41598-021-93872-8 |
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