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Novel FOXM1 inhibitor identified via gene network analysis induces autophagic FOXM1 degradation to overcome chemoresistance of human cancer cells

FOXM1 transcription factor is an oncogene and a master regulator of chemoresistance in multiple cancers. Pharmacological inhibition of FOXM1 is a promising approach but has proven to be challenging. We performed a network-centric transcriptomic analysis to identify a novel compound STL427944 that se...

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Detalles Bibliográficos
Autores principales:	Chesnokov, Mikhail S., Halasi, Marianna, Borhani, Soheila, Arbieva, Zarema, Shah, Binal N., Oerlemans, Rick, Khan, Irum, Camacho, Carlos J., Gartel, Andrei L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280155/ https://www.ncbi.nlm.nih.gov/pubmed/34262016 http://dx.doi.org/10.1038/s41419-021-03978-0

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