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Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases
How a history of influenza virus infections contributes to protection is not fully understood, but such protection might explain the contrasting age distributions of cases of the two lineages of influenza B, B/Victoria and B/Yamagata. Fitting a statistical model to those distributions using surveill...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280188/ https://www.ncbi.nlm.nih.gov/pubmed/34262041 http://dx.doi.org/10.1038/s41467-021-24566-y |
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author | Vieira, Marcos C. Donato, Celeste M. Arevalo, Philip Rimmelzwaan, Guus F. Wood, Timothy Lopez, Liza Huang, Q. Sue Dhanasekaran, Vijaykrishna Koelle, Katia Cobey, Sarah |
author_facet | Vieira, Marcos C. Donato, Celeste M. Arevalo, Philip Rimmelzwaan, Guus F. Wood, Timothy Lopez, Liza Huang, Q. Sue Dhanasekaran, Vijaykrishna Koelle, Katia Cobey, Sarah |
author_sort | Vieira, Marcos C. |
collection | PubMed |
description | How a history of influenza virus infections contributes to protection is not fully understood, but such protection might explain the contrasting age distributions of cases of the two lineages of influenza B, B/Victoria and B/Yamagata. Fitting a statistical model to those distributions using surveillance data from New Zealand, we found they could be explained by historical changes in lineage frequencies combined with cross-protection between strains of the same lineage. We found additional protection against B/Yamagata in people for whom it was their first influenza B infection, similar to the immune imprinting observed in influenza A. While the data were not informative about B/Victoria imprinting, B/Yamagata imprinting could explain the fewer B/Yamagata than B/Victoria cases in cohorts born in the 1990s and the bimodal age distribution of B/Yamagata cases. Longitudinal studies can test if these forms of protection inferred from historical data extend to more recent strains and other populations. |
format | Online Article Text |
id | pubmed-8280188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82801882021-07-23 Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases Vieira, Marcos C. Donato, Celeste M. Arevalo, Philip Rimmelzwaan, Guus F. Wood, Timothy Lopez, Liza Huang, Q. Sue Dhanasekaran, Vijaykrishna Koelle, Katia Cobey, Sarah Nat Commun Article How a history of influenza virus infections contributes to protection is not fully understood, but such protection might explain the contrasting age distributions of cases of the two lineages of influenza B, B/Victoria and B/Yamagata. Fitting a statistical model to those distributions using surveillance data from New Zealand, we found they could be explained by historical changes in lineage frequencies combined with cross-protection between strains of the same lineage. We found additional protection against B/Yamagata in people for whom it was their first influenza B infection, similar to the immune imprinting observed in influenza A. While the data were not informative about B/Victoria imprinting, B/Yamagata imprinting could explain the fewer B/Yamagata than B/Victoria cases in cohorts born in the 1990s and the bimodal age distribution of B/Yamagata cases. Longitudinal studies can test if these forms of protection inferred from historical data extend to more recent strains and other populations. Nature Publishing Group UK 2021-07-14 /pmc/articles/PMC8280188/ /pubmed/34262041 http://dx.doi.org/10.1038/s41467-021-24566-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Vieira, Marcos C. Donato, Celeste M. Arevalo, Philip Rimmelzwaan, Guus F. Wood, Timothy Lopez, Liza Huang, Q. Sue Dhanasekaran, Vijaykrishna Koelle, Katia Cobey, Sarah Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases |
title | Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases |
title_full | Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases |
title_fullStr | Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases |
title_full_unstemmed | Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases |
title_short | Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases |
title_sort | lineage-specific protection and immune imprinting shape the age distributions of influenza b cases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280188/ https://www.ncbi.nlm.nih.gov/pubmed/34262041 http://dx.doi.org/10.1038/s41467-021-24566-y |
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