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HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth

A major challenge in developing an effective vaccine against HIV-1 is the genetic diversity of its viral envelope. Because of the broad range of sequences exhibited by HIV-1 strains, protective antibodies must be able to bind and neutralize a widely mutated viral envelope protein. No vaccine has yet...

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Detalles Bibliográficos
Autores principales:	Fries, Chelsea N., Chen, Jui-Lin, Dennis, Maria L., Votaw, Nicole L., Eudailey, Joshua, Watts, Brian E., Hainline, Kelly M., Cain, Derek W., Barfield, Richard, Chan, Cliburn, Moody, M. Anthony, Haynes, Barton F., Saunders, Kevin O., Permar, Sallie R., Fouda, Genevieve G., Collier, Joel H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280189/ https://www.ncbi.nlm.nih.gov/pubmed/34262096 http://dx.doi.org/10.1038/s41598-021-93702-x

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