Cargando…

Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial

In a phase 1 randomized, single-center clinical trial, inactivated influenza virus vaccine delivered through dissolvable microneedle patches (MNPs) was found to be safe and immunogenic. Here, we compare the humoral and cellular immunologic responses in a subset of participants receiving influenza va...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rouphael, Nadine G., Lai, Lilin, Tandon, Sonia, McCullough, Michele Paine, Kong, Yunchuan, Kabbani, Sarah, Natrajan, Muktha S., Xu, Yongxian, Zhu, Yerun, Wang, Dongli, O’Shea, Jesse, Sherman, Amy, Yu, Tianwei, Henry, Sebastien, McAllister, Devin, Stadlbauer, Daniel, Khurana, Surender, Golding, Hana, Krammer, Florian, Mulligan, Mark J., Prausnitz, Mark R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280206/ https://www.ncbi.nlm.nih.gov/pubmed/34262052 http://dx.doi.org/10.1038/s41541-021-00353-0

Ejemplares similares

2739. Comparison of Hemagglutination Antibody Inhibition (HAI) Titers Following Influenza Vaccination by Birth Cohort and Repeated Influenza Vaccination History
por: Sherman, Amy C, et al.
Publicado: (2019)

Pericarditis Associated With Acute Zika Virus Infection in a Returning Traveler
por: Waggoner, Jesse J., et al.
Publicado: (2017)

The Effects of Imprinting and Repeated Seasonal Influenza Vaccination on Adaptive Immunity after Influenza Vaccination
por: Sherman, Amy C., et al.
Publicado: (2020)

Microneedle patch for immunization of immunocompromised hosts
por: Rouphael, Nadine G., et al.
Publicado: (2017)

Dissolvable Microneedle Patches to Enable Increased Access to Vaccines against SARS-CoV-2 and Future Pandemic Outbreaks
por: O’Shea, Jesse, et al.
Publicado: (2021)

Pre-Existing Dengue Immunity Drives a DENV-Biased Plasmablast Response in ZIKV-Infected Patient
por: Bhaumik, Siddhartha K., et al.
Publicado: (2018)

Biphasic Zika Illness With Rash and Joint Pain
por: Edupuganti, Srilatha, et al.
Publicado: (2017)

Blockade Antibody Responses in Human Subjects Challenged with a New Snow Mountain Virus Inoculum
por: Ibaraki, Makoto, et al.
Publicado: (2023)

Microneedle patch tattoos
por: Li, Song, et al.
Publicado: (2022)

Development of a thermostable microneedle patch for polio vaccination
por: Kolluru, Chandana, et al.
Publicado: (2018)

Collection of Analytes from Microneedle Patches
por: Romanyuk, Andrey V., et al.
Publicado: (2014)

Microneedle patch delivery of influenza vaccine during pregnancy enhances maternal immune responses promoting survival and long-lasting passive immunity to offspring
por: Esser, E. Stein, et al.
Publicado: (2017)

Effect of Surface Interactions on Microsphere Loading in Dissolving Microneedle Patches
por: Jang, Derek, et al.
Publicado: (2022)

Innate, T-, and B-Cell Responses in Acute Human Zika Patients
por: Lai, Lilin, et al.
Publicado: (2018)

Angled Insertion of Microneedles for Targeted Antigen Delivery to the Epidermis
por: Murty, Rohan, et al.
Publicado: (2022)

Clearance Kinetics and Clearance Routes of Molecules From the Suprachoroidal Space After Microneedle Injection
por: Chiang, Bryce, et al.
Publicado: (2017)

Plasmablast, Memory B Cell, CD4+ T Cell, and Circulating Follicular Helper T Cell Responses to a Non-Replicating Modified Vaccinia Ankara Vaccine
por: Anderson, Evan J., et al.
Publicado: (2020)

Suprachoroidal Delivery in Rats and Guinea Pigs Using a High-Precision Microneedle Injector
por: Hejri, Amir, et al.
Publicado: (2023)

A microneedle patch for measles and rubella vaccination: a game changer for achieving elimination
por: Prausnitz, Mark R, et al.
Publicado: (2020)

2492. Clinical, Virologic, and Immunologic Characteristics of Zika Virus Infection in a Cohort of US Patients
por: Sahly, Hana M El, et al.
Publicado: (2018)

Systems Vaccinology for a Live Attenuated Tularemia Vaccine Reveals Unique Transcriptional Signatures That Predict Humoral and Cellular Immune Responses
por: Natrajan, Muktha S., et al.
Publicado: (2019)

Prolonged Detection of Zika Virus in Vaginal Secretions and Whole Blood
por: Murray, Kristy O., et al.
Publicado: (2017)

Baseline Levels of Influenza-Specific B Cells and T Cell Responses Modulate Human Immune Responses to Swine Variant Influenza A/H3N2 Vaccine
por: Lai, Lilin, et al.
Publicado: (2020)

Transdermal Influenza Immunization with Vaccine-Coated Microneedle Arrays
por: Koutsonanos, Dimitrios G., et al.
Publicado: (2009)

Dissolving Polymer Microneedle Patches for Influenza Vaccination
por: Sullivan, Sean P., et al.
Publicado: (2010)

Administration of pilocarpine by microneedle patch as a novel method for cystic fibrosis sweat testing
por: Li, Song, et al.
Publicado: (2021)

Thickness and Closure Kinetics of the Suprachoroidal Space Following Microneedle Injection of Liquid Formulations
por: Chiang, Bryce, et al.
Publicado: (2017)

Skin immunization by microneedle patch overcomes statin-induced suppression of immune responses to influenza vaccine
por: Vassilieva, Elena V., et al.
Publicado: (2017)

Stabilization of Influenza Vaccine Enhances Protection by Microneedle Delivery in the Mouse Skin
por: Quan, Fu-Shi, et al.
Publicado: (2009)

Local Response to Microneedle-Based Influenza Immunization in the Skin
por: del Pilar Martin, Maria, et al.
Publicado: (2012)

Effect of Osmotic Pressure on the Stability of Whole Inactivated Influenza Vaccine for Coating on Microneedles
por: Choi, Hyo-Jick, et al.
Publicado: (2015)

Long-acting reversible contraception by effervescent microneedle patch
por: Li, Wei, et al.
Publicado: (2019)

Clinical, Virologic, and Immunologic Characteristics of Zika Virus Infection in a Cohort of US Patients: Prolonged RNA Detection in Whole Blood
por: El Sahly, Hana M, et al.
Publicado: (2018)

Hepatitis B vaccination using a dissolvable microneedle patch is immunogenic in mice and rhesus macaques
por: Perez Cuevas, Monica B., et al.
Publicado: (2018)

Study protocol for a phase 1/2, single-centre, double-blind, double-dummy, randomized, active-controlled, age de-escalation trial to assess the safety, tolerability and immunogenicity of a measles and rubella vaccine delivered by a microneedle patch in healthy adults (18 to 40 years), measles and rubella vaccine-primed toddlers (15 to 18 months) and measles and rubella vaccine-naïve infants (9 to 10 months) in The Gambia [Measles and Rubella Vaccine Microneedle Patch Phase 1/2 Age De-escalation Trial]
por: Adigweme, Ikechukwu, et al.
Publicado: (2022)

Effect of Adjuvants on Responses to Skin Immunization by Microneedles Coated with Influenza Subunit Vaccine
por: Weldon, William C., et al.
Publicado: (2012)

The Effect of Anticoagulants, Temperature, and Time on the Human Plasma Metabolome and Lipidome from Healthy Donors as Determined by Liquid Chromatography-Mass Spectrometry
por: Khadka, Manoj, et al.
Publicado: (2019)

Self‐healing encapsulation and controlled release of vaccine antigens from PLGA microparticles delivered by microneedle patches
por: Mazzara, J. Maxwell, et al.
Publicado: (2018)

Enhanced Immune Responses Conferring Cross-Protection by Skin Vaccination With a Tri-Component Influenza Vaccine Using a Microneedle Patch
por: Zhu, Wandi, et al.
Publicado: (2018)

Delivery of subunit influenza vaccine to skin with microneedles improves immunogenicity and long-lived protection
por: Koutsonanos, Dimitrios G., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_0mqc6s74dg5urfa8jvbnu7s3j1