Iodine containing porous organosilica nanoparticles trigger tumor spheroids destruction upon monochromatic X-ray irradiation: DNA breaks and K-edge energy X-ray

X-ray irradiation of high Z elements causes photoelectric effects that include the release of Auger electrons that can induce localized DNA breaks. We have previously established a tumor spheroid-based assay that used gadolinium containing mesoporous silica nanoparticles and synchrotron-generated mo...

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Detalles Bibliográficos
Autores principales: Higashi, Yuya, Matsumoto, Kotaro, Saitoh, Hiroyuki, Shiro, Ayumi, Ma, Yue, Laird, Mathilde, Chinnathambi, Shanmugavel, Birault, Albane, Doan, Tan Le Hoang, Yasuda, Ryo, Tajima, Toshiki, Kawachi, Tetsuya, Tamanoi, Fuyuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280225/
https://www.ncbi.nlm.nih.gov/pubmed/34262055
http://dx.doi.org/10.1038/s41598-021-93429-9

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