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Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review
Radiation therapy remains at the center of head and neck cancer treatment. With improvements in treatment delivery, radiation therapy has become an affective ablative modality for head and neck cancers. Immune checkpoint inhibitors are now also playing a more active role both in the locally advanced...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280353/ https://www.ncbi.nlm.nih.gov/pubmed/34277390 http://dx.doi.org/10.3389/fonc.2021.592319 |
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author | Hui, Caressa Chau, Brittney Gan, Greg Stokes, William Karam, Sana D. Amini, Arya |
author_facet | Hui, Caressa Chau, Brittney Gan, Greg Stokes, William Karam, Sana D. Amini, Arya |
author_sort | Hui, Caressa |
collection | PubMed |
description | Radiation therapy remains at the center of head and neck cancer treatment. With improvements in treatment delivery, radiation therapy has become an affective ablative modality for head and neck cancers. Immune checkpoint inhibitors are now also playing a more active role both in the locally advanced and metastatic setting. With improved systemic options, local noninvasive modalities including radiation therapy are playing a critical role in overcoming resistance in head and neck cancer. The aim of this review is to describe the role of radiation therapy in modulating the tumor microenvironment and how radiation dose, fractionation and treatment field can impact the immune system and potentially effect outcomes when combined with immunotherapy. The review will encompass several common scenarios where radiation is used to improve outcomes and overcome potential resistance that may develop with immunotherapy in head and neck squamous cell carcinoma (HNSCC), including upfront locally advanced disease receiving definitive radiation and recurrent disease undergoing re-irradiation. Lastly, we will review the potential toxicities of combined therapy and future directions of their role in the management of HNSCC. |
format | Online Article Text |
id | pubmed-8280353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82803532021-07-16 Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review Hui, Caressa Chau, Brittney Gan, Greg Stokes, William Karam, Sana D. Amini, Arya Front Oncol Oncology Radiation therapy remains at the center of head and neck cancer treatment. With improvements in treatment delivery, radiation therapy has become an affective ablative modality for head and neck cancers. Immune checkpoint inhibitors are now also playing a more active role both in the locally advanced and metastatic setting. With improved systemic options, local noninvasive modalities including radiation therapy are playing a critical role in overcoming resistance in head and neck cancer. The aim of this review is to describe the role of radiation therapy in modulating the tumor microenvironment and how radiation dose, fractionation and treatment field can impact the immune system and potentially effect outcomes when combined with immunotherapy. The review will encompass several common scenarios where radiation is used to improve outcomes and overcome potential resistance that may develop with immunotherapy in head and neck squamous cell carcinoma (HNSCC), including upfront locally advanced disease receiving definitive radiation and recurrent disease undergoing re-irradiation. Lastly, we will review the potential toxicities of combined therapy and future directions of their role in the management of HNSCC. Frontiers Media S.A. 2021-07-01 /pmc/articles/PMC8280353/ /pubmed/34277390 http://dx.doi.org/10.3389/fonc.2021.592319 Text en Copyright © 2021 Hui, Chau, Gan, Stokes, Karam and Amini https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Hui, Caressa Chau, Brittney Gan, Greg Stokes, William Karam, Sana D. Amini, Arya Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review |
title | Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review |
title_full | Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review |
title_fullStr | Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review |
title_full_unstemmed | Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review |
title_short | Overcoming Resistance to Immunotherapy in Head and Neck Cancer Using Radiation: A Review |
title_sort | overcoming resistance to immunotherapy in head and neck cancer using radiation: a review |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280353/ https://www.ncbi.nlm.nih.gov/pubmed/34277390 http://dx.doi.org/10.3389/fonc.2021.592319 |
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