Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors

Yes-associated protein 1 (YAP1) regulates cell plasticity during liver injury, regeneration, and cancer, but its role in liver development is unknown. We detect YAP1 activity in biliary cells and in cells at the hepatobiliary bifur-cation in single-cell RNA sequencing analysis of developing livers....

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Detalles Bibliográficos
Autores principales: Molina, Laura M., Zhu, Junjie, Li, Qin, Pradhan-Sundd, Tirthadipa, Krutsenko, Yekaterina, Sayed, Khaled, Jenkins, Nathaniel, Vats, Ravi, Bhushan, Bharat, Ko, Sungjin, Hu, Shikai, Poddar, Minakshi, Singh, Sucha, Tao, Junyan, Sundd, Prithu, Singhi, Aatur, Watkins, Simon, Ma, Xiaochao, Benos, Panayiotis V., Feranchak, Andrew, Michalopoulos, George, Nejak-Bowen, Kari, Watson, Alan, Bell, Aaron, Monga, Satdarshan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280534/
https://www.ncbi.nlm.nih.gov/pubmed/34233187
http://dx.doi.org/10.1016/j.celrep.2021.109310

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