Pathogenic ACVR1(R206H) activation by Activin A‐induced receptor clustering and autophosphorylation

Fibrodysplasia ossificans progressiva (FOP) and diffuse intrinsic pontine glioma (DIPG) are debilitating diseases that share causal mutations in ACVR1, a TGF‐β family type I receptor. ACVR1(R206H) is a frequent mutation in both diseases. Pathogenic signaling via the SMAD1/5 pathway is mediated by Ac...

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Detalles Bibliográficos
Autores principales: Ramachandran, Anassuya, Mehić, Merima, Wasim, Laabiah, Malinova, Dessislava, Gori, Ilaria, Blaszczyk, Beata K, Carvalho, Diana M, Shore, Eileen M, Jones, Chris, Hyvönen, Marko, Tolar, Pavel, Hill, Caroline S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280795/
https://www.ncbi.nlm.nih.gov/pubmed/34003511
http://dx.doi.org/10.15252/embj.2020106317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280795/
https://www.ncbi.nlm.nih.gov/pubmed/34003511
http://dx.doi.org/10.15252/embj.2020106317

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