Cargando…

Peptide Based Inhibitors of Protein Binding to the Mitogen-Activated Protein Kinase Docking Groove

Mitogen-activated protein kinases (MAPK) are important regulatory units in cells and they take part in the regulation of many cellular functions such as cell division, differentiation or apoptosis. All MAPKs have a shallow docking groove that interacts with linear binding motifs of their substrate p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alexa, Anita, Ember, Orsolya, Szabó, Ildikó, Mo’ath, Yousef, Póti, Ádám L., Reményi, Attila, Bánóczi, Zoltán
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281026/ https://www.ncbi.nlm.nih.gov/pubmed/34277705 http://dx.doi.org/10.3389/fmolb.2021.690429

Ejemplares similares

Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System
por: Szabó, Ildikó, et al.
Publicado: (2022)

Phosphorylation-Assisted Luciferase Complementation Assay Designed to Monitor Kinase Activity and Kinase-Domain-Mediated Protein–Protein Binding
por: Póti, Ádám L., et al.
Publicado: (2023)

MutDock: A computational docking approach for fixed-backbone protein scaffold design
por: Chauhan, Varun M., et al.
Publicado: (2022)

Protein Docking Model Evaluation by Graph Neural Networks
por: Wang, Xiao, et al.
Publicado: (2021)

ReverseDock: a web server for blind docking of a single ligand to multiple protein targets using AutoDock Vina
por: Krause, Fabian, et al.
Publicado: (2023)

pyDockDNA: A new web server for energy-based protein-DNA docking and scoring
por: Rodríguez-Lumbreras, Luis Angel, et al.
Publicado: (2022)

Evaluation of CONSRANK-Like Scoring Functions for Rescoring Ensembles of Protein–Protein Docking Poses
por: Launay, Guillaume, et al.
Publicado: (2020)

LZerD Protein-Protein Docking Webserver Enhanced With de novo Structure Prediction
por: Christoffer, Charles, et al.
Publicado: (2021)

Cell-Penetrating Dabcyl-Containing Tetraarginines with Backbone Aromatics as Uptake Enhancers
por: Yousef, Mo’ath, et al.
Publicado: (2022)

Activation of a Mitogen-Activated Protein Kinase Hog1 by DNA Damaging Agent Methyl Methanesulfonate in Yeast
por: Huang, Shan, et al.
Publicado: (2020)

Perspectives on High-Throughput Ligand/Protein Docking With Martini MD Simulations
por: Souza, Paulo C. T., et al.
Publicado: (2021)

RL-MLZerD: Multimeric protein docking using reinforcement learning
por: Aderinwale, Tunde, et al.
Publicado: (2022)

dMM-PBSA: A New HADDOCK Scoring Function for Protein-Peptide Docking
por: Spiliotopoulos, Dimitrios, et al.
Publicado: (2016)

Influence of the Dabcyl group on the cellular uptake of cationic peptides: short oligoarginines as efficient cell-penetrating peptides
por: Szabó, Ildikó, et al.
Publicado: (2021)

Improved Modeling of Peptide-Protein Binding Through Global Docking and Accelerated Molecular Dynamics Simulations
por: Wang, Jinan, et al.
Publicado: (2019)

Exploring rigid-backbone protein docking in biologics discovery: a test using the DARPin scaffold
por: Gaudreault, Francis, et al.
Publicado: (2023)

SeamDock: An Interactive and Collaborative Online Docking Resource to Assist Small Compound Molecular Docking
por: Murail, Samuel, et al.
Publicado: (2021)

Parallel import mechanisms ensure the robust nuclear localization of actin in Drosophila
por: Borkúti, Péter, et al.
Publicado: (2022)

NeuralDock: Rapid and Conformation-Agnostic Docking of Small Molecules
por: Sha, Congzhou M., et al.
Publicado: (2022)

Disordered–Ordered Protein Binary Classification by Circular Dichroism Spectroscopy
por: Micsonai, András, et al.
Publicado: (2022)

Exploring the Binding Interaction of Raf Kinase Inhibitory Protein With the N-Terminal of C-Raf Through Molecular Docking and Molecular Dynamics Simulation
por: Parate, Shraddha, et al.
Publicado: (2021)

Comparative Analysis of Electrostatic Models for Ligand Docking
por: Sartori, Geraldo Rodrigues, et al.
Publicado: (2019)

Investigation of bioactive compounds from Bacillus sp. against protein homologs CDC42 of Colletotrichum gloeosporioides causing anthracnose disease in cassava by using molecular docking and dynamics studies
por: Papathoti, Narendra Kumar, et al.
Publicado: (2022)

Editorial: Advances in Molecular Docking and Structure-Based Modelling
por: Rebehmed, Joseph, et al.
Publicado: (2022)

Insights from DOCK2 in cell function and pathophysiology
por: Ji, Lulin, et al.
Publicado: (2022)

A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host
por: Alexa, Anita, et al.
Publicado: (2022)

Gene expression, molecular docking, and molecular dynamics studies to identify potential antifungal compounds targeting virulence proteins/genes VelB and THR as possible drug targets against Curvularia lunata
por: Kamboj, Himanshu, et al.
Publicado: (2022)

Computational study of the binding orientation and affinity of noncovalent inhibitors of the papain-like protease (PLpro) from SARS-CoV-1 considering the protein flexibility by using molecular dynamics and cross-docking
por: Castillo-Campos, Luis, et al.
Publicado: (2023)

Engagement of intrinsic disordered proteins in protein–protein interaction
por: Roterman, Irena, et al.
Publicado: (2023)

Prediction of protein-protein interaction sites in intrinsically disordered proteins
por: Chen, Ranran, et al.
Publicado: (2022)

Protein–peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase
por: Gógl, Gergő, et al.
Publicado: (2013)

Essential Dynamics Ensemble Docking for Structure-Based GPCR Drug Discovery
por: McKay, Kyle, et al.
Publicado: (2022)

Modeling Electrostatic Force in Protein-Protein Recognition
por: Shashikala, H. B. Mihiri, et al.
Publicado: (2019)

Determining Complex Structures using Docking Method with Single Particle Scattering Data
por: Wang, Hongxiao, et al.
Publicado: (2017)

Intermolecular Communication in Bacillus subtilis: RNA-RNA, RNA-Protein and Small Protein-Protein Interactions
por: Ul Haq, Inam, et al.
Publicado: (2020)

Editorial: The Role of AAA+ Proteins in Protein Repair and Degradation
por: Shorter, James, et al.
Publicado: (2018)

NMR Methods for Structural Characterization of Protein-Protein Complexes
por: Purslow, Jeffrey A., et al.
Publicado: (2020)

Size of the protein-protein energy funnel in crowded environment
por: Jenkins, Nathan W., et al.
Publicado: (2022)

Editorial: Insights in protein biochemistry: protein biophysics 2022
por: Labrou, Nikolaos E., et al.
Publicado: (2023)

Globular and disordered—the non-identical twins in protein-protein interactions
por: Teilum, Kaare, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_c22q1nv7qe29ga651u98ua7rer