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Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors

AIM: To retrospectively investigate the pre-operative clinical factors and ultrasonographic features that influence the accuracy of the intraoperative frozen section (IFS) of ovarian tumors. PATIENTS AND METHODS: Women with ovarian tumors that underwent IFS in one tertiary medical center were recrui...

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Autores principales: Shen, Hung, Hsu, Heng-Cheng, Tai, Yi-Jou, Kuo, Kuan-Ting, Wu, Chia-Ying, Lai, Yen-Ling, Chiang, Ying-Cheng, Chen, Yu-Li, Cheng, Wen-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281203/
https://www.ncbi.nlm.nih.gov/pubmed/34277439
http://dx.doi.org/10.3389/fonc.2021.694441
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author Shen, Hung
Hsu, Heng-Cheng
Tai, Yi-Jou
Kuo, Kuan-Ting
Wu, Chia-Ying
Lai, Yen-Ling
Chiang, Ying-Cheng
Chen, Yu-Li
Cheng, Wen-Fang
author_facet Shen, Hung
Hsu, Heng-Cheng
Tai, Yi-Jou
Kuo, Kuan-Ting
Wu, Chia-Ying
Lai, Yen-Ling
Chiang, Ying-Cheng
Chen, Yu-Li
Cheng, Wen-Fang
author_sort Shen, Hung
collection PubMed
description AIM: To retrospectively investigate the pre-operative clinical factors and ultrasonographic features that influence the accuracy of the intraoperative frozen section (IFS) of ovarian tumors. PATIENTS AND METHODS: Women with ovarian tumors that underwent IFS in one tertiary medical center were recruited from January 2010 to December 2018. Demographic and clinical data of these women were retrieved from medical records in the hospital’s centralized database. RESULTS: A total of 903 ovarian tumors were enrolled, including 237 (26.2%) benign, 150 (16.6%) borderline tumor, and 516 (57.2%) malignant. The overall accuracy of IFS among all specimens was 89.9%. The sensitivities of IFS in diagnosing borderline tumors (82.0%) and malignant tumors (88.2%) were lower than in diagnosing benign tumors (98.7%, p <0.001, Z-test). The specificity of diagnosing malignant tumors (99.7%) was significantly higher than that of diagnosing benign tumors (94.7%, p <0.001, Z-test). The group with discordant IFS and final paraffin pathology (FPP) had younger age (47.2 ± 14.0 vs. 51.5 ± 11.8 years, p = 0.013, Mann–Whitney U test), and higher percentage of early-stage disease (85.2% vs. 65.1%, p = 0.001, chi-square test) and mucinous (39.3% vs. 3.3%) and endometrioid histologic types (34.4% vs. 20.2%) than the concordant group (all by chi-square test). Menopause (OR 0.34, 95% CI 0.15–0.76, p = 0.009), multicystic tumor in ultrasound (OR 2.14, 95% CI 1.14–4.01, p = 0.018), and ascites existence (OR 0.33, 95% CI 0.14–0.82, p = 0.016) were factors related to the discordant IFS by multivariate analysis. CONCLUSIONS: IFS has good accuracy in the diagnosis of ovarian tumors. We recommend more frozen tissue sampling for sonographic multicystic tumors in premenopausal women to improve the accuracy of IFS.
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spelling pubmed-82812032021-07-16 Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors Shen, Hung Hsu, Heng-Cheng Tai, Yi-Jou Kuo, Kuan-Ting Wu, Chia-Ying Lai, Yen-Ling Chiang, Ying-Cheng Chen, Yu-Li Cheng, Wen-Fang Front Oncol Oncology AIM: To retrospectively investigate the pre-operative clinical factors and ultrasonographic features that influence the accuracy of the intraoperative frozen section (IFS) of ovarian tumors. PATIENTS AND METHODS: Women with ovarian tumors that underwent IFS in one tertiary medical center were recruited from January 2010 to December 2018. Demographic and clinical data of these women were retrieved from medical records in the hospital’s centralized database. RESULTS: A total of 903 ovarian tumors were enrolled, including 237 (26.2%) benign, 150 (16.6%) borderline tumor, and 516 (57.2%) malignant. The overall accuracy of IFS among all specimens was 89.9%. The sensitivities of IFS in diagnosing borderline tumors (82.0%) and malignant tumors (88.2%) were lower than in diagnosing benign tumors (98.7%, p <0.001, Z-test). The specificity of diagnosing malignant tumors (99.7%) was significantly higher than that of diagnosing benign tumors (94.7%, p <0.001, Z-test). The group with discordant IFS and final paraffin pathology (FPP) had younger age (47.2 ± 14.0 vs. 51.5 ± 11.8 years, p = 0.013, Mann–Whitney U test), and higher percentage of early-stage disease (85.2% vs. 65.1%, p = 0.001, chi-square test) and mucinous (39.3% vs. 3.3%) and endometrioid histologic types (34.4% vs. 20.2%) than the concordant group (all by chi-square test). Menopause (OR 0.34, 95% CI 0.15–0.76, p = 0.009), multicystic tumor in ultrasound (OR 2.14, 95% CI 1.14–4.01, p = 0.018), and ascites existence (OR 0.33, 95% CI 0.14–0.82, p = 0.016) were factors related to the discordant IFS by multivariate analysis. CONCLUSIONS: IFS has good accuracy in the diagnosis of ovarian tumors. We recommend more frozen tissue sampling for sonographic multicystic tumors in premenopausal women to improve the accuracy of IFS. Frontiers Media S.A. 2021-07-01 /pmc/articles/PMC8281203/ /pubmed/34277439 http://dx.doi.org/10.3389/fonc.2021.694441 Text en Copyright © 2021 Shen, Hsu, Tai, Kuo, Wu, Lai, Chiang, Chen and Cheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Shen, Hung
Hsu, Heng-Cheng
Tai, Yi-Jou
Kuo, Kuan-Ting
Wu, Chia-Ying
Lai, Yen-Ling
Chiang, Ying-Cheng
Chen, Yu-Li
Cheng, Wen-Fang
Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors
title Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors
title_full Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors
title_fullStr Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors
title_full_unstemmed Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors
title_short Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors
title_sort factors influencing the discordancy between intraoperative frozen sections and final paraffin pathologies in ovarian tumors
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281203/
https://www.ncbi.nlm.nih.gov/pubmed/34277439
http://dx.doi.org/10.3389/fonc.2021.694441
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