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Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019
BACKGROUND: Chronic kidney disease (CKD) is a public health problem largely caused by diabetes. The epidemiology of diabetes mellitus–related CKD (CKD-DM) could provide specific support to lessen global, regional, and national CKD burden. METHODS: Data were derived from the GBD 2019 study, including...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281340/ https://www.ncbi.nlm.nih.gov/pubmed/34276558 http://dx.doi.org/10.3389/fendo.2021.672350 |
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author | Deng, Yujiao Li, Na Wu, Ying Wang, Meng Yang, Si Zheng, Yi Deng, Xinyue Xiang, Dong Zhu, Yuyao Xu, Peng Zhai, Zhen Zhang, Dai Dai, Zhijun Gao, Jie |
author_facet | Deng, Yujiao Li, Na Wu, Ying Wang, Meng Yang, Si Zheng, Yi Deng, Xinyue Xiang, Dong Zhu, Yuyao Xu, Peng Zhai, Zhen Zhang, Dai Dai, Zhijun Gao, Jie |
author_sort | Deng, Yujiao |
collection | PubMed |
description | BACKGROUND: Chronic kidney disease (CKD) is a public health problem largely caused by diabetes. The epidemiology of diabetes mellitus–related CKD (CKD-DM) could provide specific support to lessen global, regional, and national CKD burden. METHODS: Data were derived from the GBD 2019 study, including four measures and age-standardized rates (ASRs). Estimated annual percentage changes and 95% CIs were calculated to evaluate the variation trend of ASRs. RESULTS: Diabetes caused the majority of new cases and patients with CKD in all regions. All ASRs for type 2 diabetes–related CKD increased over 30 years. Asia and Middle socio-demographic index (SDI) quintile always carried the heaviest burden of CKD-DM. Diabetes type 2 became the second leading cause of CKD and CKD-related death and the third leading cause of CKD-related DALYs in 2019. Type 2 diabetes–related CKD accounted for most of the CKD-DM disease burden. There were 2.62 million incident cases, 134.58 million patients, 405.99 thousand deaths, and 13.09 million disability-adjusted life-years (DALYs) of CKD-DM worldwide in 2019. Age-standardized incidence (ASIR) and prevalence rate (ASPR) of type 1 diabetes–related CKD increased, whereas age-standardized death rate (ASDR) and DALY rate decreased for females and increased for males. In high SDI quintile, ASIR and ASPR of type 1 diabetes–related CKD remained the highest, with the slowest increase, whereas the ASDR and age-standardized DALY rate remained the lowest there. In high SDI quintile, ASIR of type 2 diabetes–related CKD was the highest, with the lowest increasing rate. In addition, type 2 diabetes–related CKD occurred most in people aged 80-plus years worldwide. The main age of type 2 diabetes–related CKD patients was 55–64 years in Asia and Africa. The prevalence, mortality, and DALY rate of type 2 diabetes–related CKD increased with age. As for incidence, there was a peak at 80 years, and after age of 80, the incidence declined. CKD-DM-related anemia was mainly in mild to moderate grade. CONCLUSIONS: Increasing burden of CKD-DM varied among regions and countries. Prevention and treatment measures should be strengthened according to CKD-DM epidemiology, especially in middle SDI quintile and Asia. |
format | Online Article Text |
id | pubmed-8281340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82813402021-07-16 Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019 Deng, Yujiao Li, Na Wu, Ying Wang, Meng Yang, Si Zheng, Yi Deng, Xinyue Xiang, Dong Zhu, Yuyao Xu, Peng Zhai, Zhen Zhang, Dai Dai, Zhijun Gao, Jie Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Chronic kidney disease (CKD) is a public health problem largely caused by diabetes. The epidemiology of diabetes mellitus–related CKD (CKD-DM) could provide specific support to lessen global, regional, and national CKD burden. METHODS: Data were derived from the GBD 2019 study, including four measures and age-standardized rates (ASRs). Estimated annual percentage changes and 95% CIs were calculated to evaluate the variation trend of ASRs. RESULTS: Diabetes caused the majority of new cases and patients with CKD in all regions. All ASRs for type 2 diabetes–related CKD increased over 30 years. Asia and Middle socio-demographic index (SDI) quintile always carried the heaviest burden of CKD-DM. Diabetes type 2 became the second leading cause of CKD and CKD-related death and the third leading cause of CKD-related DALYs in 2019. Type 2 diabetes–related CKD accounted for most of the CKD-DM disease burden. There were 2.62 million incident cases, 134.58 million patients, 405.99 thousand deaths, and 13.09 million disability-adjusted life-years (DALYs) of CKD-DM worldwide in 2019. Age-standardized incidence (ASIR) and prevalence rate (ASPR) of type 1 diabetes–related CKD increased, whereas age-standardized death rate (ASDR) and DALY rate decreased for females and increased for males. In high SDI quintile, ASIR and ASPR of type 1 diabetes–related CKD remained the highest, with the slowest increase, whereas the ASDR and age-standardized DALY rate remained the lowest there. In high SDI quintile, ASIR of type 2 diabetes–related CKD was the highest, with the lowest increasing rate. In addition, type 2 diabetes–related CKD occurred most in people aged 80-plus years worldwide. The main age of type 2 diabetes–related CKD patients was 55–64 years in Asia and Africa. The prevalence, mortality, and DALY rate of type 2 diabetes–related CKD increased with age. As for incidence, there was a peak at 80 years, and after age of 80, the incidence declined. CKD-DM-related anemia was mainly in mild to moderate grade. CONCLUSIONS: Increasing burden of CKD-DM varied among regions and countries. Prevention and treatment measures should be strengthened according to CKD-DM epidemiology, especially in middle SDI quintile and Asia. Frontiers Media S.A. 2021-07-01 /pmc/articles/PMC8281340/ /pubmed/34276558 http://dx.doi.org/10.3389/fendo.2021.672350 Text en Copyright © 2021 Deng, Li, Wu, Wang, Yang, Zheng, Deng, Xiang, Zhu, Xu, Zhai, Zhang, Dai and Gao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Deng, Yujiao Li, Na Wu, Ying Wang, Meng Yang, Si Zheng, Yi Deng, Xinyue Xiang, Dong Zhu, Yuyao Xu, Peng Zhai, Zhen Zhang, Dai Dai, Zhijun Gao, Jie Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019 |
title | Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019 |
title_full | Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019 |
title_fullStr | Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019 |
title_full_unstemmed | Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019 |
title_short | Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019 |
title_sort | global, regional, and national burden of diabetes-related chronic kidney disease from 1990 to 2019 |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281340/ https://www.ncbi.nlm.nih.gov/pubmed/34276558 http://dx.doi.org/10.3389/fendo.2021.672350 |
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