Cargando…

Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019

BACKGROUND: Chronic kidney disease (CKD) is a public health problem largely caused by diabetes. The epidemiology of diabetes mellitus–related CKD (CKD-DM) could provide specific support to lessen global, regional, and national CKD burden. METHODS: Data were derived from the GBD 2019 study, including...

Descripción completa

Detalles Bibliográficos
Autores principales: Deng, Yujiao, Li, Na, Wu, Ying, Wang, Meng, Yang, Si, Zheng, Yi, Deng, Xinyue, Xiang, Dong, Zhu, Yuyao, Xu, Peng, Zhai, Zhen, Zhang, Dai, Dai, Zhijun, Gao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281340/
https://www.ncbi.nlm.nih.gov/pubmed/34276558
http://dx.doi.org/10.3389/fendo.2021.672350
_version_ 1783722826587439104
author Deng, Yujiao
Li, Na
Wu, Ying
Wang, Meng
Yang, Si
Zheng, Yi
Deng, Xinyue
Xiang, Dong
Zhu, Yuyao
Xu, Peng
Zhai, Zhen
Zhang, Dai
Dai, Zhijun
Gao, Jie
author_facet Deng, Yujiao
Li, Na
Wu, Ying
Wang, Meng
Yang, Si
Zheng, Yi
Deng, Xinyue
Xiang, Dong
Zhu, Yuyao
Xu, Peng
Zhai, Zhen
Zhang, Dai
Dai, Zhijun
Gao, Jie
author_sort Deng, Yujiao
collection PubMed
description BACKGROUND: Chronic kidney disease (CKD) is a public health problem largely caused by diabetes. The epidemiology of diabetes mellitus–related CKD (CKD-DM) could provide specific support to lessen global, regional, and national CKD burden. METHODS: Data were derived from the GBD 2019 study, including four measures and age-standardized rates (ASRs). Estimated annual percentage changes and 95% CIs were calculated to evaluate the variation trend of ASRs. RESULTS: Diabetes caused the majority of new cases and patients with CKD in all regions. All ASRs for type 2 diabetes–related CKD increased over 30 years. Asia and Middle socio-demographic index (SDI) quintile always carried the heaviest burden of CKD-DM. Diabetes type 2 became the second leading cause of CKD and CKD-related death and the third leading cause of CKD-related DALYs in 2019. Type 2 diabetes–related CKD accounted for most of the CKD-DM disease burden. There were 2.62 million incident cases, 134.58 million patients, 405.99 thousand deaths, and 13.09 million disability-adjusted life-years (DALYs) of CKD-DM worldwide in 2019. Age-standardized incidence (ASIR) and prevalence rate (ASPR) of type 1 diabetes–related CKD increased, whereas age-standardized death rate (ASDR) and DALY rate decreased for females and increased for males. In high SDI quintile, ASIR and ASPR of type 1 diabetes–related CKD remained the highest, with the slowest increase, whereas the ASDR and age-standardized DALY rate remained the lowest there. In high SDI quintile, ASIR of type 2 diabetes–related CKD was the highest, with the lowest increasing rate. In addition, type 2 diabetes–related CKD occurred most in people aged 80-plus years worldwide. The main age of type 2 diabetes–related CKD patients was 55–64 years in Asia and Africa. The prevalence, mortality, and DALY rate of type 2 diabetes–related CKD increased with age. As for incidence, there was a peak at 80 years, and after age of 80, the incidence declined. CKD-DM-related anemia was mainly in mild to moderate grade. CONCLUSIONS: Increasing burden of CKD-DM varied among regions and countries. Prevention and treatment measures should be strengthened according to CKD-DM epidemiology, especially in middle SDI quintile and Asia.
format Online
Article
Text
id pubmed-8281340
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82813402021-07-16 Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019 Deng, Yujiao Li, Na Wu, Ying Wang, Meng Yang, Si Zheng, Yi Deng, Xinyue Xiang, Dong Zhu, Yuyao Xu, Peng Zhai, Zhen Zhang, Dai Dai, Zhijun Gao, Jie Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Chronic kidney disease (CKD) is a public health problem largely caused by diabetes. The epidemiology of diabetes mellitus–related CKD (CKD-DM) could provide specific support to lessen global, regional, and national CKD burden. METHODS: Data were derived from the GBD 2019 study, including four measures and age-standardized rates (ASRs). Estimated annual percentage changes and 95% CIs were calculated to evaluate the variation trend of ASRs. RESULTS: Diabetes caused the majority of new cases and patients with CKD in all regions. All ASRs for type 2 diabetes–related CKD increased over 30 years. Asia and Middle socio-demographic index (SDI) quintile always carried the heaviest burden of CKD-DM. Diabetes type 2 became the second leading cause of CKD and CKD-related death and the third leading cause of CKD-related DALYs in 2019. Type 2 diabetes–related CKD accounted for most of the CKD-DM disease burden. There were 2.62 million incident cases, 134.58 million patients, 405.99 thousand deaths, and 13.09 million disability-adjusted life-years (DALYs) of CKD-DM worldwide in 2019. Age-standardized incidence (ASIR) and prevalence rate (ASPR) of type 1 diabetes–related CKD increased, whereas age-standardized death rate (ASDR) and DALY rate decreased for females and increased for males. In high SDI quintile, ASIR and ASPR of type 1 diabetes–related CKD remained the highest, with the slowest increase, whereas the ASDR and age-standardized DALY rate remained the lowest there. In high SDI quintile, ASIR of type 2 diabetes–related CKD was the highest, with the lowest increasing rate. In addition, type 2 diabetes–related CKD occurred most in people aged 80-plus years worldwide. The main age of type 2 diabetes–related CKD patients was 55–64 years in Asia and Africa. The prevalence, mortality, and DALY rate of type 2 diabetes–related CKD increased with age. As for incidence, there was a peak at 80 years, and after age of 80, the incidence declined. CKD-DM-related anemia was mainly in mild to moderate grade. CONCLUSIONS: Increasing burden of CKD-DM varied among regions and countries. Prevention and treatment measures should be strengthened according to CKD-DM epidemiology, especially in middle SDI quintile and Asia. Frontiers Media S.A. 2021-07-01 /pmc/articles/PMC8281340/ /pubmed/34276558 http://dx.doi.org/10.3389/fendo.2021.672350 Text en Copyright © 2021 Deng, Li, Wu, Wang, Yang, Zheng, Deng, Xiang, Zhu, Xu, Zhai, Zhang, Dai and Gao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Deng, Yujiao
Li, Na
Wu, Ying
Wang, Meng
Yang, Si
Zheng, Yi
Deng, Xinyue
Xiang, Dong
Zhu, Yuyao
Xu, Peng
Zhai, Zhen
Zhang, Dai
Dai, Zhijun
Gao, Jie
Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019
title Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019
title_full Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019
title_fullStr Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019
title_full_unstemmed Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019
title_short Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019
title_sort global, regional, and national burden of diabetes-related chronic kidney disease from 1990 to 2019
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281340/
https://www.ncbi.nlm.nih.gov/pubmed/34276558
http://dx.doi.org/10.3389/fendo.2021.672350
work_keys_str_mv AT dengyujiao globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019
AT lina globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019
AT wuying globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019
AT wangmeng globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019
AT yangsi globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019
AT zhengyi globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019
AT dengxinyue globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019
AT xiangdong globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019
AT zhuyuyao globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019
AT xupeng globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019
AT zhaizhen globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019
AT zhangdai globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019
AT daizhijun globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019
AT gaojie globalregionalandnationalburdenofdiabetesrelatedchronickidneydiseasefrom1990to2019