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Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation

Plasmalogens are membrane glycerophospholipids with diverse biological functions. Reduced plasmalogen levels have been observed in metabolic diseases; hence, increasing their levels might be beneficial in ameliorating these conditions. Shark liver oil (SLO) is a rich source of alkylglycerols that ca...

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Autores principales: Paul, Sudip, Smith, Adam Alexander T., Culham, Kevin, Gunawan, Kevin A., Weir, Jacqueline M., Cinel, Michelle A., Jayawardana, Kaushala S., Mellett, Natalie A., Lee, Man K.S., Murphy, Andrew J., Lancaster, Graeme I., Nestel, Paul J., Kingwell, Bronwyn A., Meikle, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281607/
https://www.ncbi.nlm.nih.gov/pubmed/34146594
http://dx.doi.org/10.1016/j.jlr.2021.100092
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author Paul, Sudip
Smith, Adam Alexander T.
Culham, Kevin
Gunawan, Kevin A.
Weir, Jacqueline M.
Cinel, Michelle A.
Jayawardana, Kaushala S.
Mellett, Natalie A.
Lee, Man K.S.
Murphy, Andrew J.
Lancaster, Graeme I.
Nestel, Paul J.
Kingwell, Bronwyn A.
Meikle, Peter J.
author_facet Paul, Sudip
Smith, Adam Alexander T.
Culham, Kevin
Gunawan, Kevin A.
Weir, Jacqueline M.
Cinel, Michelle A.
Jayawardana, Kaushala S.
Mellett, Natalie A.
Lee, Man K.S.
Murphy, Andrew J.
Lancaster, Graeme I.
Nestel, Paul J.
Kingwell, Bronwyn A.
Meikle, Peter J.
author_sort Paul, Sudip
collection PubMed
description Plasmalogens are membrane glycerophospholipids with diverse biological functions. Reduced plasmalogen levels have been observed in metabolic diseases; hence, increasing their levels might be beneficial in ameliorating these conditions. Shark liver oil (SLO) is a rich source of alkylglycerols that can be metabolized into plasmalogens. This study was designed to evaluate the impact of SLO supplementation on endogenous plasmalogen levels in individuals with features of metabolic disease. In this randomized, double-blind, placebo-controlled cross-over study, the participants (10 overweight or obese males) received 4-g Alkyrol® (purified SLO) or placebo (methylcellulose) per day for 3 weeks followed by a 3-week washout phase and were then crossed over to 3 weeks of the alternate placebo/Alkyrol® treatment. SLO supplementation led to significant changes in plasma and circulatory white blood cell lipidomes, notably increased levels of plasmalogens and other ether lipids. In addition, SLO supplementation significantly decreased the plasma levels of total free cholesterol, triglycerides, and C-reactive protein. These findings suggest that SLO supplementation can enrich plasma and cellular plasmalogens and this enrichment may provide protection against obesity-related dyslipidemia and inflammation.
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spelling pubmed-82816072021-07-21 Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation Paul, Sudip Smith, Adam Alexander T. Culham, Kevin Gunawan, Kevin A. Weir, Jacqueline M. Cinel, Michelle A. Jayawardana, Kaushala S. Mellett, Natalie A. Lee, Man K.S. Murphy, Andrew J. Lancaster, Graeme I. Nestel, Paul J. Kingwell, Bronwyn A. Meikle, Peter J. J Lipid Res Research Article Plasmalogens are membrane glycerophospholipids with diverse biological functions. Reduced plasmalogen levels have been observed in metabolic diseases; hence, increasing their levels might be beneficial in ameliorating these conditions. Shark liver oil (SLO) is a rich source of alkylglycerols that can be metabolized into plasmalogens. This study was designed to evaluate the impact of SLO supplementation on endogenous plasmalogen levels in individuals with features of metabolic disease. In this randomized, double-blind, placebo-controlled cross-over study, the participants (10 overweight or obese males) received 4-g Alkyrol® (purified SLO) or placebo (methylcellulose) per day for 3 weeks followed by a 3-week washout phase and were then crossed over to 3 weeks of the alternate placebo/Alkyrol® treatment. SLO supplementation led to significant changes in plasma and circulatory white blood cell lipidomes, notably increased levels of plasmalogens and other ether lipids. In addition, SLO supplementation significantly decreased the plasma levels of total free cholesterol, triglycerides, and C-reactive protein. These findings suggest that SLO supplementation can enrich plasma and cellular plasmalogens and this enrichment may provide protection against obesity-related dyslipidemia and inflammation. American Society for Biochemistry and Molecular Biology 2021-06-17 /pmc/articles/PMC8281607/ /pubmed/34146594 http://dx.doi.org/10.1016/j.jlr.2021.100092 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Paul, Sudip
Smith, Adam Alexander T.
Culham, Kevin
Gunawan, Kevin A.
Weir, Jacqueline M.
Cinel, Michelle A.
Jayawardana, Kaushala S.
Mellett, Natalie A.
Lee, Man K.S.
Murphy, Andrew J.
Lancaster, Graeme I.
Nestel, Paul J.
Kingwell, Bronwyn A.
Meikle, Peter J.
Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation
title Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation
title_full Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation
title_fullStr Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation
title_full_unstemmed Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation
title_short Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation
title_sort shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281607/
https://www.ncbi.nlm.nih.gov/pubmed/34146594
http://dx.doi.org/10.1016/j.jlr.2021.100092
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