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Downregulation of FeSOD-A expression in Leishmania infantum alters trivalent antimony and miltefosine susceptibility

BACKGROUND: Superoxide dismutase (SOD), a central component of the antioxidant defence system of most organisms, removes excess superoxide anions by converting them to oxygen and hydrogen peroxide. As iron (Fe) SOD is absent in the human host, this enzyme is a promising molecular target for drug dev...

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Detalles Bibliográficos
Autores principales:	Santi, Ana Maria Murta, Silva, Paula Alves, Santos, Isabella Fernandes Martins, Murta, Silvane Maria Fonseca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281622/ https://www.ncbi.nlm.nih.gov/pubmed/34266485 http://dx.doi.org/10.1186/s13071-021-04838-8

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