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Perceived physical health outcomes of direct-acting antiviral treatment for hepatitis C: a qualitative study

BACKGROUND: Novel health promotion and treatment uptake initiatives will be necessary to ensure Australia meets 2030 hepatitis C elimination targets. Increasing treatment uptake will be assisted by a better understanding of the treatment experience and patient-perceived benefits. This study describe...

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Autores principales: Goutzamanis, Stelliana, Horyniak, Danielle, Doyle, Joseph S., Hellard, Margaret, Higgs, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281623/
https://www.ncbi.nlm.nih.gov/pubmed/34266434
http://dx.doi.org/10.1186/s12954-021-00516-1
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author Goutzamanis, Stelliana
Horyniak, Danielle
Doyle, Joseph S.
Hellard, Margaret
Higgs, Peter
author_facet Goutzamanis, Stelliana
Horyniak, Danielle
Doyle, Joseph S.
Hellard, Margaret
Higgs, Peter
author_sort Goutzamanis, Stelliana
collection PubMed
description BACKGROUND: Novel health promotion and treatment uptake initiatives will be necessary to ensure Australia meets 2030 hepatitis C elimination targets. Increasing treatment uptake will be assisted by a better understanding of the treatment experience and patient-perceived benefits. This study describes the perceived physical health benefits from direct-acting antiviral (DAA) hepatitis C treatment among people who inject drugs in Melbourne, Australia. METHODS: Twenty participants were recruited from a community treatment trial and community health clinics. Semi-structured interviews were performed with each participant before, during and following treatment. Interviews focused on treatment experiences, attitudes and motivations. Interviews were recorded, transcribed and thematically analysed. RESULTS: Two themes relating to the physical experience of treatment developed; intersection between physical and mental health and “maybe it’s working”. Participants reported various physical benefits, most prominently, reduced fatigue. Reductions in fatigue resulted in instant and meaningful changes in everyday life. Some participants did experience side effects, which they described as mild. Experiencing noticeable physical benefits during treatment was perceived as validation that treatment was working. CONCLUSION: Physical health benefits of DAA treatment may have carry-on effects on cognitive, emotional or social wellbeing and should be incorporated into how treatment is promoted to those who require it.
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spelling pubmed-82816232021-07-16 Perceived physical health outcomes of direct-acting antiviral treatment for hepatitis C: a qualitative study Goutzamanis, Stelliana Horyniak, Danielle Doyle, Joseph S. Hellard, Margaret Higgs, Peter Harm Reduct J Brief Report BACKGROUND: Novel health promotion and treatment uptake initiatives will be necessary to ensure Australia meets 2030 hepatitis C elimination targets. Increasing treatment uptake will be assisted by a better understanding of the treatment experience and patient-perceived benefits. This study describes the perceived physical health benefits from direct-acting antiviral (DAA) hepatitis C treatment among people who inject drugs in Melbourne, Australia. METHODS: Twenty participants were recruited from a community treatment trial and community health clinics. Semi-structured interviews were performed with each participant before, during and following treatment. Interviews focused on treatment experiences, attitudes and motivations. Interviews were recorded, transcribed and thematically analysed. RESULTS: Two themes relating to the physical experience of treatment developed; intersection between physical and mental health and “maybe it’s working”. Participants reported various physical benefits, most prominently, reduced fatigue. Reductions in fatigue resulted in instant and meaningful changes in everyday life. Some participants did experience side effects, which they described as mild. Experiencing noticeable physical benefits during treatment was perceived as validation that treatment was working. CONCLUSION: Physical health benefits of DAA treatment may have carry-on effects on cognitive, emotional or social wellbeing and should be incorporated into how treatment is promoted to those who require it. BioMed Central 2021-07-15 /pmc/articles/PMC8281623/ /pubmed/34266434 http://dx.doi.org/10.1186/s12954-021-00516-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Brief Report
Goutzamanis, Stelliana
Horyniak, Danielle
Doyle, Joseph S.
Hellard, Margaret
Higgs, Peter
Perceived physical health outcomes of direct-acting antiviral treatment for hepatitis C: a qualitative study
title Perceived physical health outcomes of direct-acting antiviral treatment for hepatitis C: a qualitative study
title_full Perceived physical health outcomes of direct-acting antiviral treatment for hepatitis C: a qualitative study
title_fullStr Perceived physical health outcomes of direct-acting antiviral treatment for hepatitis C: a qualitative study
title_full_unstemmed Perceived physical health outcomes of direct-acting antiviral treatment for hepatitis C: a qualitative study
title_short Perceived physical health outcomes of direct-acting antiviral treatment for hepatitis C: a qualitative study
title_sort perceived physical health outcomes of direct-acting antiviral treatment for hepatitis c: a qualitative study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281623/
https://www.ncbi.nlm.nih.gov/pubmed/34266434
http://dx.doi.org/10.1186/s12954-021-00516-1
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