Review of applications of CRISPR-Cas9 gene-editing technology in cancer research

Characterized by multiple complex mutations, including activation by oncogenes and inhibition by tumor suppressors, cancer is one of the leading causes of death. Application of CRISPR-Cas9 gene-editing technology in cancer research has aroused great interest, promoting the exploration of the molecul...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Ziyi, Li, Chenxi, Tong, Fei, Deng, Jingkuang, Huang, Guofu, Sang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281662/
https://www.ncbi.nlm.nih.gov/pubmed/34261433
http://dx.doi.org/10.1186/s12575-021-00151-x
_version_ 1783722871777918976
author Zhao, Ziyi
Li, Chenxi
Tong, Fei
Deng, Jingkuang
Huang, Guofu
Sang, Yi
author_facet Zhao, Ziyi
Li, Chenxi
Tong, Fei
Deng, Jingkuang
Huang, Guofu
Sang, Yi
author_sort Zhao, Ziyi
collection PubMed
description Characterized by multiple complex mutations, including activation by oncogenes and inhibition by tumor suppressors, cancer is one of the leading causes of death. Application of CRISPR-Cas9 gene-editing technology in cancer research has aroused great interest, promoting the exploration of the molecular mechanism of cancer progression and development of precise therapy. CRISPR-Cas9 gene-editing technology provides a solid basis for identifying driver and passenger mutations in cancer genomes, which is of great value in genetic screening and for developing cancer models and treatments. This article reviews the current applications of CRISPR-Cas9 gene-editing technology in various cancer studies, the challenges faced, and the existing solutions, highlighting the potential of this technology for cancer treatment.
format Online
Article
Text
id pubmed-8281662
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-82816622021-07-16 Review of applications of CRISPR-Cas9 gene-editing technology in cancer research Zhao, Ziyi Li, Chenxi Tong, Fei Deng, Jingkuang Huang, Guofu Sang, Yi Biol Proced Online Review Characterized by multiple complex mutations, including activation by oncogenes and inhibition by tumor suppressors, cancer is one of the leading causes of death. Application of CRISPR-Cas9 gene-editing technology in cancer research has aroused great interest, promoting the exploration of the molecular mechanism of cancer progression and development of precise therapy. CRISPR-Cas9 gene-editing technology provides a solid basis for identifying driver and passenger mutations in cancer genomes, which is of great value in genetic screening and for developing cancer models and treatments. This article reviews the current applications of CRISPR-Cas9 gene-editing technology in various cancer studies, the challenges faced, and the existing solutions, highlighting the potential of this technology for cancer treatment. BioMed Central 2021-07-15 /pmc/articles/PMC8281662/ /pubmed/34261433 http://dx.doi.org/10.1186/s12575-021-00151-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhao, Ziyi
Li, Chenxi
Tong, Fei
Deng, Jingkuang
Huang, Guofu
Sang, Yi
Review of applications of CRISPR-Cas9 gene-editing technology in cancer research
title Review of applications of CRISPR-Cas9 gene-editing technology in cancer research
title_full Review of applications of CRISPR-Cas9 gene-editing technology in cancer research
title_fullStr Review of applications of CRISPR-Cas9 gene-editing technology in cancer research
title_full_unstemmed Review of applications of CRISPR-Cas9 gene-editing technology in cancer research
title_short Review of applications of CRISPR-Cas9 gene-editing technology in cancer research
title_sort review of applications of crispr-cas9 gene-editing technology in cancer research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281662/
https://www.ncbi.nlm.nih.gov/pubmed/34261433
http://dx.doi.org/10.1186/s12575-021-00151-x
work_keys_str_mv AT zhaoziyi reviewofapplicationsofcrisprcas9geneeditingtechnologyincancerresearch
AT lichenxi reviewofapplicationsofcrisprcas9geneeditingtechnologyincancerresearch
AT tongfei reviewofapplicationsofcrisprcas9geneeditingtechnologyincancerresearch
AT dengjingkuang reviewofapplicationsofcrisprcas9geneeditingtechnologyincancerresearch
AT huangguofu reviewofapplicationsofcrisprcas9geneeditingtechnologyincancerresearch
AT sangyi reviewofapplicationsofcrisprcas9geneeditingtechnologyincancerresearch

Ejemplares similares