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Representing a Heterogeneous Pharmaceutical Knowledge-Graph with Textual Information

We deal with a heterogeneous pharmaceutical knowledge-graph containing textual information built from several databases. The knowledge graph is a heterogeneous graph that includes a wide variety of concepts and attributes, some of which are provided in the form of textual pieces of information which...

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Autores principales: Asada, Masaki, Gunasekaran, Nallappan, Miwa, Makoto, Sasaki, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281808/
https://www.ncbi.nlm.nih.gov/pubmed/34278204
http://dx.doi.org/10.3389/frma.2021.670206
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author Asada, Masaki
Gunasekaran, Nallappan
Miwa, Makoto
Sasaki, Yutaka
author_facet Asada, Masaki
Gunasekaran, Nallappan
Miwa, Makoto
Sasaki, Yutaka
author_sort Asada, Masaki
collection PubMed
description We deal with a heterogeneous pharmaceutical knowledge-graph containing textual information built from several databases. The knowledge graph is a heterogeneous graph that includes a wide variety of concepts and attributes, some of which are provided in the form of textual pieces of information which have not been targeted in the conventional graph completion tasks. To investigate the utility of textual information for knowledge graph completion, we generate embeddings from textual descriptions given to heterogeneous items, such as drugs and proteins, while learning knowledge graph embeddings. We evaluate the obtained graph embeddings on the link prediction task for knowledge graph completion, which can be used for drug discovery and repurposing. We also compare the results with existing methods and discuss the utility of the textual information.
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spelling pubmed-82818082021-07-16 Representing a Heterogeneous Pharmaceutical Knowledge-Graph with Textual Information Asada, Masaki Gunasekaran, Nallappan Miwa, Makoto Sasaki, Yutaka Front Res Metr Anal Research Metrics and Analytics We deal with a heterogeneous pharmaceutical knowledge-graph containing textual information built from several databases. The knowledge graph is a heterogeneous graph that includes a wide variety of concepts and attributes, some of which are provided in the form of textual pieces of information which have not been targeted in the conventional graph completion tasks. To investigate the utility of textual information for knowledge graph completion, we generate embeddings from textual descriptions given to heterogeneous items, such as drugs and proteins, while learning knowledge graph embeddings. We evaluate the obtained graph embeddings on the link prediction task for knowledge graph completion, which can be used for drug discovery and repurposing. We also compare the results with existing methods and discuss the utility of the textual information. Frontiers Media S.A. 2021-07-01 /pmc/articles/PMC8281808/ /pubmed/34278204 http://dx.doi.org/10.3389/frma.2021.670206 Text en Copyright © 2021 Asada, Gunasekaran, Miwa and Sasaki. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Research Metrics and Analytics
Asada, Masaki
Gunasekaran, Nallappan
Miwa, Makoto
Sasaki, Yutaka
Representing a Heterogeneous Pharmaceutical Knowledge-Graph with Textual Information
title Representing a Heterogeneous Pharmaceutical Knowledge-Graph with Textual Information
title_full Representing a Heterogeneous Pharmaceutical Knowledge-Graph with Textual Information
title_fullStr Representing a Heterogeneous Pharmaceutical Knowledge-Graph with Textual Information
title_full_unstemmed Representing a Heterogeneous Pharmaceutical Knowledge-Graph with Textual Information
title_short Representing a Heterogeneous Pharmaceutical Knowledge-Graph with Textual Information
title_sort representing a heterogeneous pharmaceutical knowledge-graph with textual information
topic Research Metrics and Analytics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281808/
https://www.ncbi.nlm.nih.gov/pubmed/34278204
http://dx.doi.org/10.3389/frma.2021.670206
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