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Human Beta-Defensin 2 and 3 Inhibit HIV-1 Replication in Macrophages

Human beta-defensins (hBDs) are broad-spectrum antimicrobial peptides, secreted by epithelial cells of the skin and mucosae, and astrocytes, which we and others have shown to inhibit HIV-1 in primary CD4(+) T cells. Although loss of CD4(+) T cells contributes to mucosal immune dysfunction, macrophag...

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Detalles Bibliográficos
Autores principales:	Bharucha, Jennifer P., Sun, Lingling, Lu, Wuyuan, Gartner, Suzanne, Garzino-Demo, Alfredo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281893/ https://www.ncbi.nlm.nih.gov/pubmed/34277460 http://dx.doi.org/10.3389/fcimb.2021.535352

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