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Short- and long-term outcomes of infective endocarditis admission in adults: A population-based registry study in Finland

Infective endocarditis (IE) is associated with high mortality. However, data on factors associated with length of stay (LOS) in hospital due to IE are scarce. In addition, long-term mortality of more than 1 year is inadequately known. In this large population-based study we investigated age and sex...

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Autores principales: Ahtela, Elina, Oksi, Jarmo, Vahlberg, Tero, Sipilä, Jussi, Rautava, Päivi, Kytö, Ville
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282023/
https://www.ncbi.nlm.nih.gov/pubmed/34265019
http://dx.doi.org/10.1371/journal.pone.0254553
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author Ahtela, Elina
Oksi, Jarmo
Vahlberg, Tero
Sipilä, Jussi
Rautava, Päivi
Kytö, Ville
author_facet Ahtela, Elina
Oksi, Jarmo
Vahlberg, Tero
Sipilä, Jussi
Rautava, Päivi
Kytö, Ville
author_sort Ahtela, Elina
collection PubMed
description Infective endocarditis (IE) is associated with high mortality. However, data on factors associated with length of stay (LOS) in hospital due to IE are scarce. In addition, long-term mortality of more than 1 year is inadequately known. In this large population-based study we investigated age and sex differences, temporal trends, and factors affecting the LOS in patients with IE and in-hospital, 1-year, 5-year and 10-year mortality of IE. Data on patients (≥18 years of age) admitted to hospital due to IE in Finland during 2005–2014 were collected retrospectively from nationwide obligatory registries. We included 2166 patients in our study. Of the patients 67.8% were men. Women were older than men (mean age 63.3 vs. 59.5, p<0.001). The median LOS was 20.0 days in men and 18.0 in women, p = 0.015. In the youngest patients (18–39 years) the median LOS was significantly longer than in the oldest patients (≥80 years) (24.0 vs. 16.0 days, p = 0.014). In-hospital mortality was 10% with no difference between men and women. Mortality was 22.7% at 1 year whereas 5- and 10-year mortality was 37.5% and 48.5%, respectively. The 5-year and 10-year mortality was higher in women (HR 1.18, p = 0.034; HR 1.18, p = 0.021). Both in-hospital and long-term mortality increased significantly with aging and comorbidity burden. Both mortality and LOS remained stable over the study period. In conclusion, men had longer hospital stays due to IE compared to women. The 5- and 10-year mortality was higher in women. The mortality of IE or LOS did not change over time.
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spelling pubmed-82820232021-07-28 Short- and long-term outcomes of infective endocarditis admission in adults: A population-based registry study in Finland Ahtela, Elina Oksi, Jarmo Vahlberg, Tero Sipilä, Jussi Rautava, Päivi Kytö, Ville PLoS One Research Article Infective endocarditis (IE) is associated with high mortality. However, data on factors associated with length of stay (LOS) in hospital due to IE are scarce. In addition, long-term mortality of more than 1 year is inadequately known. In this large population-based study we investigated age and sex differences, temporal trends, and factors affecting the LOS in patients with IE and in-hospital, 1-year, 5-year and 10-year mortality of IE. Data on patients (≥18 years of age) admitted to hospital due to IE in Finland during 2005–2014 were collected retrospectively from nationwide obligatory registries. We included 2166 patients in our study. Of the patients 67.8% were men. Women were older than men (mean age 63.3 vs. 59.5, p<0.001). The median LOS was 20.0 days in men and 18.0 in women, p = 0.015. In the youngest patients (18–39 years) the median LOS was significantly longer than in the oldest patients (≥80 years) (24.0 vs. 16.0 days, p = 0.014). In-hospital mortality was 10% with no difference between men and women. Mortality was 22.7% at 1 year whereas 5- and 10-year mortality was 37.5% and 48.5%, respectively. The 5-year and 10-year mortality was higher in women (HR 1.18, p = 0.034; HR 1.18, p = 0.021). Both in-hospital and long-term mortality increased significantly with aging and comorbidity burden. Both mortality and LOS remained stable over the study period. In conclusion, men had longer hospital stays due to IE compared to women. The 5- and 10-year mortality was higher in women. The mortality of IE or LOS did not change over time. Public Library of Science 2021-07-15 /pmc/articles/PMC8282023/ /pubmed/34265019 http://dx.doi.org/10.1371/journal.pone.0254553 Text en © 2021 Ahtela et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ahtela, Elina
Oksi, Jarmo
Vahlberg, Tero
Sipilä, Jussi
Rautava, Päivi
Kytö, Ville
Short- and long-term outcomes of infective endocarditis admission in adults: A population-based registry study in Finland
title Short- and long-term outcomes of infective endocarditis admission in adults: A population-based registry study in Finland
title_full Short- and long-term outcomes of infective endocarditis admission in adults: A population-based registry study in Finland
title_fullStr Short- and long-term outcomes of infective endocarditis admission in adults: A population-based registry study in Finland
title_full_unstemmed Short- and long-term outcomes of infective endocarditis admission in adults: A population-based registry study in Finland
title_short Short- and long-term outcomes of infective endocarditis admission in adults: A population-based registry study in Finland
title_sort short- and long-term outcomes of infective endocarditis admission in adults: a population-based registry study in finland
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282023/
https://www.ncbi.nlm.nih.gov/pubmed/34265019
http://dx.doi.org/10.1371/journal.pone.0254553
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