Multivalent designed proteins protect against SARS-CoV-2 variants of concern

Escape variants of SARS-CoV-2 are threatening to prolong the COVID-19 pandemic. To address this challenge, we developed multivalent protein-based minibinders as potential prophylactic and therapeutic agents. Homotrimers of single minibinders and fusions of three distinct minibinders were designed to...

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Detalles Bibliográficos
Autores principales: Hunt, Andrew C., Case, James Brett, Park, Young-Jun, Cao, Longxing, Wu, Kejia, Walls, Alexandra C., Liu, Zhuoming, Bowen, John E., Yeh, Hsien-Wei, Saini, Shally, Helms, Louisa, Zhao, Yan Ting, Hsiang, Tien-Ying, Starr, Tyler N., Goreshnik, Inna, Kozodoy, Lisa, Carter, Lauren, Ravichandran, Rashmi, Green, Lydia B., Matochko, Wadim L., Thomson, Christy A., Vögeli, Bastain, Krüger-Gericke, Antje, VanBlargan, Laura A., Chen, Rita E., Ying, Baoling, Bailey, Adam L., Kafai, Natasha M., Boyken, Scott, Ljubetič, Ajasja, Edman, Natasha, Ueda, George, Chow, Cameron, Addetia, Amin, Panpradist, Nuttada, Gale, Michael, Freedman, Benjamin S., Lutz, Barry R., Bloom, Jesse D., Ruohola-Baker, Hannele, Whelan, Sean P. J., Stewart, Lance, Diamond, Michael S., Veesler, David, Jewett, Michael C., Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282097/
https://www.ncbi.nlm.nih.gov/pubmed/34268509
http://dx.doi.org/10.1101/2021.07.07.451375

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