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Oxidative Stress Activated by Sorafenib Alters the Temozolomide Sensitivity of Human Glioma Cells Through Autophagy and JAK2/STAT3-AIF Axis

The development of temozolomide (TMZ) resistance in glioma leads to poor patient prognosis. Sorafenib, a novel diaryl urea compound and multikinase inhibitor, has the ability to effectively cross the blood-brain barrier. However, the effect of sorafenib on glioma cells and the molecular mechanism un...

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Detalles Bibliográficos
Autores principales:	Wei, Jianwei, Wang, Zhengfeng, Wang, Weiwei, Liu, Xiaoge, Wan, Junhu, Yuan, Yongjie, Li, Xueyuan, Ma, Liwei, Liu, Xianzhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282178/ https://www.ncbi.nlm.nih.gov/pubmed/34277607 http://dx.doi.org/10.3389/fcell.2021.660005

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